1) oxazaborolidine
噁唑硼烷
1.
The asymmetric reduction of ketosulfone with borane catalyzed by oxazaborolidine is computed by means of the semi-empirical MNDO method.
对噁唑硼烷催化前手性酮砜不对称还原反应进行了半经验MNDO研究。
2.
Asymmetric reduction of prochiral ketones using oxazaborolidines has become one of the standard tools for the synthetic chemist, allowing access to enantiomerically enriched secondary alcohols with excellent enantiomeric excess that may seve as the chiral ligands for enantionselectivity synthesis and highly useful intermediates in the sy.
手性噁唑硼烷催化前手性酮的不对称还原反应已成为合成化学家的重要手段之一,这种方法获得的手性仲醇具有较高的ee 值,它们可作为不对称合成中的手性配体及活性物质、天然产物和药物的手性中间体。
2) 1,3,2-oxazaborolidine
1,3,2-噁唑硼烷
1.
The enantioselective reduction of phenyl methyl ketone catalyzed by 1,3,2-oxazaborolidine has been studied by AM1-SCF MO method.
本文用AM1分子轨道方法研究了1,3,2-噁唑硼烷对苯甲酮的不对称催化还原。
4) chiral oxazaborolidine
手性噁唑硼烷
1.
The asymmetric reduction of 3-chloropropiophenone catalyzed by chiral oxazaborolidines enantioselectively gave S- or R-3-chloro-1-phenylpropanol (2) in good yield.
以自制的手性噁唑硼烷为催化剂,将起始原料β-氯苯丙酮不对称催化氢化还原成(S)-或(R)-手性醇,这一步的化学收率和光学收率都较高。
2.
The asymmetric reduction of ethyl γ-chloroacetoacetate catalyzed by chiral oxazaborolidines enantioselectively gave ethyl R-3-hydroxy-4-chlorobutyrate in good yield and enantioselectivity.
以自制的手性噁唑硼烷为催化剂,将起始原料γ-氯乙酰乙酸乙酯不对称催化氢化还原成(R)-γ-氯-β-羟基丁酸乙酯,这一步的化学收率和光学收率都较高。
3.
The formed chiral oxazaborolidines in situ have been used in the enantioselective borane reduction of prochiral ketones affording the alcohol products with enantiomeric excesses (ee) up to 96%.
首次以天然D-樟脑的衍生物为原料,合成了两个新型龙脑基氨基醇配体,研究了它们与硼烷原位制备成手性噁唑硼烷后,在不对称催化氢化还原前手性芳酮中的性能,得到的手性仲醇的对映体过量(ee)值最高可达96%,还考察了反应温度、时间、溶剂等因素对苯乙酮的不对称氢化还原的化学产率和光学收率的影响。
5) oxazaborolidine catalyst
噁唑硼烷催化剂
补充资料：(R)-4-苯基-2-噁唑烷酮
分子式：C9H9NO2
分子量：163.17
CAS号：90319-52-1
性质：熔点129-132°C。比旋光度-49.5° (c=2, CHCl3)。
分子量：163.17
CAS号：90319-52-1
性质：熔点129-132°C。比旋光度-49.5° (c=2, CHCl3)。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条