1) activity of γ-secreatase
γ分泌酶活性
2) γ-secretase
γ分泌酶
1.
Assembly of γ-secretase for production of β-amyloid;
催化淀粉样蛋白产生的γ分泌酶的组装
2.
Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).
膜蛋白presenilin1(PS1)是γ分泌酶的催化组分,是催化产生β淀粉样蛋白(β-amyloid,Aβ)的关键蛋白酶,因此也是治疗阿尔茨海默病(Alzheimer’s disease,AD)的主要靶点。
3.
Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.
处理超表达组(T)和对照组(C)细胞,并收集纯化过程中含γ分泌酶复合物的样本,用Western blotting检测γ分泌酶复合物重要组分Nicastrin(NCT)、Presenilin-1(PS-1)以及TMP21的蛋白表达量。
3) γ-secretase
γ-分泌酶
1.
Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;
利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
2.
Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;
γ-分泌酶组分基因APH-1A和PEN-2的转录调控
3.
Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.
Aβ是由淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶(BACE)和γ-分泌酶水解产生的,因此BACE1在AD的形成过程中发挥重要作用。
4) β-and γ-secretase
β-和γ-分泌酶
1.
Objective To investigate the effects of Chinese herb compound Shen-wu capsule on the metabolism of β-amyloid(Aβ) and β-and γ-secretase in β-amyloid precursor protein(APP) transgenic mice.
目的观察中药新复方参乌胶囊对β-淀粉样肽前体蛋白(APP)转基因小鼠脑内β-淀粉样肽(Aβ)代谢及β-和γ-分泌酶的影响。
5) γ-secretase inhibitors
γ-分泌酶抑制剂
1.
Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect;
兼有神经保护作用的γ-分泌酶抑制剂的计算机辅助设计、合成及初步活性实验研究
2.
Methods A series of compounds were designed,synthesized,and evaluated based on pharmacophore model of γ-secretase inhibitors by virtual screening in MDL.
目的通过在数据库中虚拟筛选,以期发现新的γ-分泌酶抑制剂。
6) β-or γ-secretase
β-或γ-分泌酶
补充资料：酒化酶、醇酶、发酵酶
分子式：
CAS号：
性质：又称酒化酶、醇酶、发酵酶。从酵母中分离而得的一系列酶。不耐热。它能催化酒精发酵反应，与糖酵解有关，如磷酸化酶、醛缩酶、葡萄糖磷酸变位酶、葡萄糖6-磷酸酶等。
CAS号：
性质：又称酒化酶、醇酶、发酵酶。从酵母中分离而得的一系列酶。不耐热。它能催化酒精发酵反应，与糖酵解有关，如磷酸化酶、醛缩酶、葡萄糖磷酸变位酶、葡萄糖6-磷酸酶等。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条