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1)  Valproate Semisodium
丙戊酸半钠
2)  sodium valproate
丙戊酸钠
1.
Clinical analysis of the effects of sodium valproate on adult refractory status epilepticus;
丙戊酸钠注射液治疗成人难治性癫痫持续状态的临床效果分析
2.
Control study of lithium carbonate combined with sodium valproate in the treatment of acute manic episode;
碳酸锂联用丙戊酸钠治疗急性躁狂对照研究
3.
Effect of sodium valproate on serum concentration and clinical efficacy of clozapine;
丙戊酸钠对氯氮平血药浓度和疗效的影响
3)  valproate [英][væl'prəueit]  [美][væl'proet]
丙戊酸钠
1.
Effects of lamotrigine and sodium valproate on cognitive function in patients with epilepsy:a comparative study;
拉莫三嗪与丙戊酸钠对癫痫患者认知功能影响对比研究
2.
Valproate provides a protective effect against 6-OHDA induced apoptosis in SH-SY5Y cells;
丙戊酸钠对6-OHDA诱导的SH-SY5Y细胞凋亡的保护作用及其机制
3.
The Study Progress of Valproate about its Weight Gain Associated with and its Influence on Leptin;
丙戊酸钠诱发体质量增加与瘦素影响的研究
4)  Valproic Acid
丙戊酸钠
1.
Effect of Valproic Acid on Motor Neurons in Spinal Cord After Sciatic Nerve Injury in Rats;
丙戊酸钠对大鼠坐骨神经损伤后脊髓运动神经元的保护作用
2.
Efficacy and tolerability of topiramate versus valproic acid in adults newly diagnosed with epilepsy;
托吡酯与丙戊酸钠对照治疗成人癫痫124例
3.
Monitoring the concentration of Valproic acid and its clinical sense;
丙戊酸钠血药浓度监测及意义
5)  sodium valprate
丙戊酸钠
1.
HPLC determination of sodium valprate in the serum after precolumn derivatization;
柱前衍生高效液相色谱法测定人血清中丙戊酸钠浓度
2.
Rapid determination of sodium valprate in serum by HPLC after precolumn derivatization;
柱前衍生-高效液相色谱法测定丙戊酸钠血药浓度
6)  Valproate sodium
丙戊酸钠
1.
Methodes:Eighty adult Wistar rats were randomlydivided into normalcontrol (NP)group,PTZ group,Valproate Sodium(VAP) durg positive Low dose group(25 mg/kg /d),medium dose group(38 mg/kg/d),high dose group(76 mg/kg/d), Oxcarbazepine(OXC) treatment Low dose group(165 mg/kg/d),medium dose group(250 mg/kg/d),high dose group(500 mg/kg/d),10 in each group.
方法:将80只成年Wistar大鼠随机分为8个组,正常对照组、模型组、丙戊酸钠阳性药物对照低剂量组(25 mg/kg/d)、中剂量组(38 mg/kg/d)、高剂量组(76 mg/kg/d)、奥卡西平药物治疗低剂量组(165 mg/kg/d)、中剂量组(250 mg/kg/d)、高剂量组(500 mg/kg/d)、每组10只。
2.
Valproate sodium could decrease the phosphorylation of P-CREB1 in effective dose.
目的:研究丙戊酸钠对大鼠海马神经元癫痫样放电后磷酸化腺感苷反应元件结合蛋白1(Phosphorylated cAMP responsive element binding protein 1,P-CREB1)表达的影响。
补充资料:丙戊酸
分子式:C8H16O2
分子量:144.21
CAS号:99-66-1

性质:无色液体。沸点221℃,相对密度1.1(24.5/4℃),折光率1.4250,闪点111℃。难溶于水。

制备方法:由二丙基丙二酸经消除脱羧而得。将二丙基丙二酸投入反应锅,加热至180℃,反应物渐渐熔化,逸出大量二氧化碳气体。消除反应结束后,减压蒸馏,收集112-114℃(0.93-1.06kPa)馏分,即为2-丙基戊酸,收率86%。

用途:该品与氢氧化钠溶液成盐,得到广谱抗癫痫熔药物丙戊酸钠,又称抗癫灵。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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