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1)  TrkB
酪氨酸激酶B
1.
Objective To investigate expression of brain-derived neurotrophic factor(BDNF)TrkB and TrkB mRNA in cerebral cortex and hippocampus in bilirubin-induced encephalopathy by establishing an experimental model and to explore their roles and mechanism of action so as to provide a new approach for treatment of the disease.
目的通过实验观察胆红素脑病时脑源性神经营养因子的特异性受体酪氨酸激酶B酪氨酸激酶B信使RNA在大脑皮层及海马的表达,探讨其在胆红素脑病中可能的作用及机制,为新生儿胆红素脑病新的治疗途径提供实验依据。
2.
Objective:The experiment will study the learning and memory ability of AD rats and the quantity of BDNF、TrkB and CREB in order to study the therapeutically effect and mechanism of the electroacupuncture(EA) on Alzheimer disease(AD), which will offer experimental basis of applying EA in clinic practice of the acupuncture-moxibustion.
目的:通过研究电针风府穴对AD大鼠学习记忆能力、脑源性神经营养因子(Brain-derivedneurotrophiefactor,BDNF)及其受体酪氨酸激酶B(Tyrosinekinase-B,TrkB)阳性神经元数量、cAMP反应元件结合蛋白(cAMP responsive element binding protein,CREB)阳性神经元数量的影响,探讨电针风府穴对AD治疗作用及其作用机理,为针灸临床提供实验依据。
2)  Tyrosine kinase B
酪氨酸激酶B
1.
Tyrosine kinase B expression correlates with perineural invasion in salivary adenoid cystic carcinoma.;
酪氨酸激酶B在涎腺腺样囊性癌中的表达及与嗜神经侵袭的关系
2.
Objective:To investigate the relationship of the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B(TrkB) to salivary adenoid cystic carcinoma(SACC).
目的:探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)及其受体酪氨酸激酶B(tyrosine kinase B,TrkB)与涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)的关系。
3)  TrkB
酪氨酸激酶受体B
1.
The Expression of BDNF and TrkB in Rat Cerebellum;
脑源性神经营养因子及酪氨酸激酶受体B在大鼠小脑的表达
2.
Background and purpose:TrkB, a neurotrophic tyrosine kinase receptor,serves as a potent and specific suppressor of anoikis of non-malignant epithelial cells, and confers high metastatic capacity to these cells.
背景与目的:失巢凋亡抑制因子酪氨酸激酶受体B(tyrosine kinase receptor, TrkB)能诱导正常上皮细胞的恶性转化并且使该细胞具有高转移能力。
3.
Background and purpose:TrkB,a neurotrophic tyrosine kinase receptor,serves as a potent and specific suppressor of anoikis of non-malignant epithelial cells,and induces high invasion capacity in these cells.
背景与目的:失巢凋亡抑制因子酪氨酸激酶受体B(tyrosine kinase receptor,TrkB)能诱导正常上皮细胞的恶性转化并且使该细胞具有高侵袭能力。
4)  Tyrosine kinase receptor B
酪氨酸蛋白激酶受体B
1.
Expression of tyrosine kinase receptor B in human follicle;
酪氨酸蛋白激酶受体B在人卵泡中的表达及意义
2.
BDNF initiate its biological effects by bounding to tyrosine kinase receptor B (TrkB) on the cell membrane.
目的:关于人卵泡液中存在着由卵丘颗粒细胞分泌的脑源性神经营养因子(BDNF)的报道提示:人卵巢中可能有BDNF赖以发挥其生物学效应的特异性高亲合力受体—酪氨酸蛋白激酶受体B(TrkB)的存在。
5)  trkB
酪氨酸蛋白激酶B
6)  TrkB
酪氨酸激酶B受体
1.
Study on the Expression of BDNF and TrkB in Rat Hippocampal Formation CA1;
脑源性神经营养因子及酪氨酸激酶B受体在大鼠海马结构CA_1区的表达研究
补充资料:酪氨酸蛋白激酶抑制剂
分子式:
CAS号:

性质:一类能抑制蛋白质酪氨酸激酶活性的化合物。酪氨酸蛋白激酶能特异性地将磷酸根转移到蛋白质的酪氨酸残基上使其磷酸化,是许多配体活化的生长因子受体和一些癌基因产物,在肿瘤组织中含量高。酪氨酸蛋白激酶抑制剂可作为ATP与酪氨酸蛋白激酶结合的竞争性抑制剂,也可作为酪氨酸的类似物阻断表皮生长因子受体的肽位点和酪氨酸蛋白激酶的编码,抑制细胞增殖,可望开发为抗肿瘤药物,但对完整细胞没有表现出选择性。

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