1) Humanization
[英][hju:mənai'zeiʃən] [美][hjumənə'zeʃən]
人源化
1.
Progress in monoclonal antibody humanization based on complementarity-determining region grafting;
基于互补决定区移植的单抗人源化进展
2.
Cloning of mouse R5 gene and vector construction for humanization based on CDR homology;
小鼠单抗R5基因的克隆和基于CDR相似性的人源化质粒构建
3.
Humanization of anti-human fibrin single-chain antibody;
抗人纤维蛋白单链抗体的人源化
2) Humanized
[英]['hju:mənaiz] [美]['hjumən,aɪz]
人源化
1.
The important role of platelet in bleeding and thrombotic diseases, the present status of development on study of humanized anti-platelet antibody and its application in treatment of bleeding and thrombotic diseases were summarized in this review.
抗血小板人源化抗体在治疗特发性血小板减少性紫癜和防止血栓性疾病方面有极大的临床应用价值。
2.
Objective To construct and express a humanized anti-CD3 single chain Fv fragment(ScFv),which would be a promising candidate for the construction of a recombinant anti-CD3/anti-glioma BsAb with small size and more potency.
方法 从质粒 pZZ3中克隆出人源化抗CD3抗体的VH、VL 基因后 ,构建人源化抗CD3单链抗体基因 ,将其克隆入表达载体 pGEX - 5X1中后转化大肠杆菌 ,以IPTG诱导表达。
3) humanized Fab
人源化Fab
1.
Construction of phage antibody library with predetermined CDR3 gene and screening of humanized Fab of anti-human integrin ανβ_3 monoclonal antibody;
构建预设CDR3基因噬菌体抗体库筛选抗人整合素ανβ_3 mAb的人源化Fab
4) hMN14,1111In
人源化MN14,111In
5) humanized model
人源化模型
6) Humanized antibody
人源化抗体
1.
The expression of humanized antibody containing mutated Fc region (hu12F6m) was confirmed by ELISA and RT-PCR.
为了降低抗CD3人源化抗体hu12F6对T细胞的激活作用以克服首剂效应 ,构建了恒定区特定位点突变的hu12F6重链表达载体 ,将其与hu12F6的轻链表达载体共转染CHO细胞 。
2.
Binding of the humanized antibody to the EGFR was assessed by Surface Plasmon Renainance with Biacore3000,and the biological activity of the humanized antibody was determined by tumor cell invasion test.
结果:成功构建3种不同突变体表达载体C2、C3和C5,纯化的抗体在还原SDS-PAGE中表现为相对分子质量约为25×103和50×103两条带;免疫印迹分析表明,该人源化抗体可与羊抗人IgG特异性结合。
补充资料：公理化方法(见公理化和形式化)
公理化方法(见公理化和形式化)
axiomatical method
gongllbuafangfa公理化方法化和形式化。(axiomatieal method)见公理
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条