1) loss of heterozygosity
杂合缺失
1.
Loss of heterozygosity of chromosome 22 in sporadic colorectal carcinoma;
散发性结直肠癌22号染色体等位基因杂合缺失
2.
Methods: Mutation in exon 3 of β-catenin gene and mutation cluster region of APC gene, loss of heterozygosity and methylation status of promoter 1A of APC gene in breast cancer and normal tissue around tumor were detected by polymerase chain reaction-single strand conformation polymorphism, microsatellite analysis and methylation specific PCR.
方法:应用PCR-SSCP、微卫星标记、甲基化特异性PCR方法检测乳腺癌和癌旁正常乳腺组织中β-catenin基因外显子3和APC基因突变密集区突变、APC基因杂合缺失(LOH)和启动子1A区甲基化状态,用RT-PCR检测APC基因mRNA表达;并用免疫组织化学法检测APC和β-catenin蛋白表达。
3.
Objective Loss of heterozygosity (LOH) of tumor suppressor gene(TSG) is believed to play a key role in carcinogenesis of colorectal cancer (CRC).
目的抑癌基因的杂合缺失(LOH)被认为是结直肠癌形成的通路之一,本实验拟通过对染色体10q23～24区的LOH分析,发现高频杂合缺失区域并筛查与结直肠癌相关的抑癌基因。
2) LOH
杂合缺失
1.
Detection of allele-specific chromosome 3p25 by PCR -LOH in 35 cases of esophageal carcinoma;
食管癌患者3p25等位基因杂合缺失的初步研究
2.
Methods: We performed restriction fragment length polymorphism (RFLP) analysis by using the polymerase chain reaction (PCR) and primer sets of two DNA markers to examine loss of heterozygosity (LOH) from 3p in glioma samples.
方法 :应用 PCR技术配合限制性片段长度多态性 (RFL P)分析 ,对胶质瘤 3号染色体短臂3p2 4两个 DNA标志不同位点的杂合缺失 (L OH)进行检测。
3) loss of heterozygosity
杂合性缺失
1.
Identification of some macrosatillite sites of chromosome 19 in primary gastric carcinoma with loss of heterozygosity;
19号染色体微卫星杂合性缺失与原发性胃癌的临床关系
2.
Analysis of loss of heterozygosity in tk gene of L5178Y mouse lymphoma cells induced by colchicine and vincristine;
秋水仙碱和长春新碱诱导L5178Y小鼠淋巴瘤细胞tk基因杂合性缺失分析
3.
Study of loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma;
胃癌FHIT基因杂合性缺失及微卫星不稳定性的研究
4) LOH
杂合性缺失
1.
Study on 10q23 LOH and Both Mutation and Expression of PTEN Gene of the Oesophageal Squamous Cell Carcinomas in Chinese Population;
中国人食管癌10q23杂合性缺失和PTEN基因突变及表达研究
2.
Methods PCR-denaturing polyacrylamide gel electrophoresis-silver staining method was used to detect LOH of three mic- rusatellite locus located in the WWOX gene site of 31 breast cancer tissues.
目的检测乳腺癌组织中WWOX基因的杂合性缺失(LOH)状况及WWOX蛋白的表达状况,并探讨其与乳腺癌临床病理参数之间的关系。
3.
Objective:To detect the loss of heterozygosity(LOH) of ING1 gene microsatellite and the expression of p33ING1b protein in lung carcinoma and to investigate their association with the carcinogenesis of lung cancer.
目的:检测肺癌中抑癌基因ING1微卫星杂合性缺失(LOH)及其主要蛋白产物p33ING1b的表达情况,以探讨ING1基因改变与肺癌发生发展的关系。
6) Loss of hererozygosity
杂合型缺失
补充资料：二氯化(1,4,8,12-四氮杂环十五烷)合镍
分子式：
CAS号：
性质：蓝色晶体。熔点99～100℃。溶于甲醇、二氯甲烷、乙腈。用二氯化镍、N,N′-双(3-氨基丙基)-1,3-丙二胺、乙二醛水溶液,以Raney镍为催化剂,加氢制得。与氰化钠水溶液反应则得相应的配体。用作化学试剂。
CAS号：
性质：蓝色晶体。熔点99～100℃。溶于甲醇、二氯甲烷、乙腈。用二氯化镍、N,N′-双(3-氨基丙基)-1,3-丙二胺、乙二醛水溶液,以Raney镍为催化剂,加氢制得。与氰化钠水溶液反应则得相应的配体。用作化学试剂。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条