Designing Synthesis and Bioactivities of α-Aminophosphonates Containing 3,4,5-Trimethoxyphenyl;

Separation of enantiomers of fluorine-containing α-aminophosphonate by high performance liquid chromatography on the amylose chiral solid phase

5 h to afford the title compound α-aminophosphonate 4 in good yield.

Then we developed a microwave-assisted, catalyst-free and solvent-free reaction for the synthesis ofα-amino phosphonates (9a～9l).

The lanthanide compounds catalyzed synthesis of 1,5-benzodiazepines and stereoselective synthesis of heterocyclicα-amino phosphonates are studied in this thesis, which is composed with three parts as follows: 1.

Nine new water soluble α-amino phosphonate esters were synthesized from the addition reaction of salicylaldehyde amino acid Schiff base with dialkylphosphite.

Progress in synthesis of α-aminophosphonates,including Lewis catalytic synthesis,free-Lewis catalytic synthesis and green synthesis,were reviewed with 33 references.

α-Aminophosphonates, analogues of natural amino acids, are an important class of active compounds.

Since stereochemistry at theα-carbon atom plays an important role in the biological activity of the molecule,enantioselective Brφnsted acid catalyzed synthesis ofα-aminophosphonates has become an area of considerable attention.

Study on the Synthesis of α-iminophophonates;