As the isosteric or bio-isosteric analogues of the corresponding α-amino acids, α-aminophosphonic acids have diverse and interesting biological and biochemical properties.

Designing Synthesis and Bioactivities of α-Aminophosphonates Containing 3,4,5-Trimethoxyphenyl;

Separation of enantiomers of fluorine-containing α-aminophosphonate by high performance liquid chromatography on the amylose chiral solid phase

5 h to afford the title compound α-aminophosphonate 4 in good yield.

Then we developed a microwave-assisted, catalyst-free and solvent-free reaction for the synthesis ofα-amino phosphonates (9a～9l).

The lanthanide compounds catalyzed synthesis of 1,5-benzodiazepines and stereoselective synthesis of heterocyclicα-amino phosphonates are studied in this thesis, which is composed with three parts as follows: 1.