1) DNA injury and DNA repair
DNA损伤与DNA修复
2) DNA damage and repair
DNA损伤与修复
1.
Study on DNA damage and repair induced by deoxynivalenol in cultured Vero cell with Comet Assay;
脱氧雪腐镰刀菌烯醇致Vero细胞核基因组DNA损伤与修复的彗星实验观察
2.
Objective To investigate the sensitivity to Adriamycin of down-regulated cells expressed hOGG1 gene which target to oxidative DNA damage and repair,and provide more experimental evidence of sensitizing the response of tumor to chemotherapy.
方法用不同剂量的阿霉素处理肺腺癌A 549细胞和通过稳定转染hOGG 1核酶而获得的hOGG 1低表达的A 549-R细胞,用M TT法测定两种细胞的存活率;体外微核试验及单细胞凝胶电泳检测两种细胞微核率及DNA损伤与修复的差异;流式细胞术检测周期分布、凋亡率和细胞增殖指数。
3.
Deinococcus radiodurans,as a model organism in DNA damage and repair,is the most resistant bacterium to ionizing radiation.
耐辐射奇球菌是迄今为止发现的对辐射抗性最强的原核生物,是研究DNA损伤与修复的模式生物。
4) DNA repair
DNA损伤修复
1.
To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway.
目前已经发现至少12种FA基因的缺失或突变能够引起FA表型的出现,其中10种相应的编码蛋白形成FA复合物共同参与FA/BRCA2 DNA损伤修复途径—FA途径。
2.
Previous studies show that p33 ING1b is involved in growth inhibition, apoptosis, chromatin remodeling, DNA repair, tumor suppression and cellular senescence, but its biochemical function and involvement in cellular senescence is still not fully uncharacterized.
p33ING1b是一个较晚发现的肿瘤抑制基因ING1的主要表达形式,但是它在细胞衰老过程中的作用特别是对衰老细胞DNA损伤修复的影响还没有被阐明。
3.
Objective:To establish and characterize mouse medulloblastoma(MB) cell lines with PARP-1 mutation,in order to explore the molecular machanism of MB,and to investigate the impact of PARP-1 on DNA repair proteins including Brca1、Nbs1、Ku70、Ku80 and RAD51 in the MB cells.
目的:利用PARP-1和p53基因双缺失的小鼠髓母细胞瘤细胞系,探讨DNA损伤修复因子Brca1、Nbs1、Ku70、Ku80和Rad51对小鼠髓母细胞瘤发生的意义及其相互作用关系。
5) DNA damage repair
DNA损伤修复
1.
The functions of BRCA1 and BRCA2 in DNA damage repair and transcriptional regulation;
BRCA1和BRCA2与DNA损伤修复及转录调控
2.
Cultured A-T cells lack radiation-induced cell cycle checkpoints and express cellular defects that correlate with the clinical phenotype, such as the defect of DNA damage repair capacity and a high rate of apoptosis.
人拓扑异构酶Ⅲ(human topoisomeraseⅢ，hTOP3)基因具有介导DNA损伤修复的功能。
3.
Studies on irradiation-resistant bacteria and their mechanism of DNA damage repair have been received considerable attention from the scientific community.
极端耐辐射微生物和耐辐射微生物DNA损伤修复机制研究对于环境保护和生物修复、人类健康以及生物技术创新等有着重大的理论和应用意义,是目前全球研究的热点。
6) DNA damage and repair
DNA损伤修复
1.
Establishment of thymocytes DNA damage and repair model;
MNNG诱导小鼠胸腺细胞DNA损伤修复模型的建立
2.
It formed multiple complexes with different regulatory subunits and participated in many cellular progresses such as centrosome maturation, spicesome assembly, regulation of many pathways and regulation of DNA damage and repair.
蛋白磷酸酶4(PP4或PPX)是蛋白磷酸酶2A(PP2A)家族的重要成员之一,它与多个调节亚基形成多种复合体参与诸多重要的细胞进程,如中心体的成熟、剪接体复合体的组装、多个细胞信号通路的调节以及DNA损伤修复的调节等多个事件。
3.
[Objectives] To investigate the expressions of JWA and heat shock protein 70 (hsp70) in cccHPF-1 cells after exposed to activated B(a)P, and to explore the role and the possible mechanism of JWA gene involved in B(a)P -induced DNA damage and repair.
[目的]研究苯并[a]芘[benzo(a)pyrene,B(a)P]诱导人胚肺细胞(ccc-HPF-1)DNA损伤修复中,JWA和热休克蛋白70(heat shock protein 70,hsp70)的表达规律,探讨JWA参与细胞DNA损伤修复的作用和可能机制。
补充资料：DNA损伤试验
分子式：
CAS号：
性质：一种检测化学物质的短期致突变/致癌性试验方法。常用培养的哺乳动物细胞系(株)作试验用生物体，以肝微粒体酶系(S9组分)作为活化系统。在合适的剂量(浓度)范围内，于二氧化碳孵化箱培养条件下进行试验。多应用同位素示踪法显示，主要检出DNA损伤后生成的单链断裂。其标准化方法有碱性蔗糖梯度沉降法和碱性洗脱法检出单链断裂，作为DNA损伤的判断。碱性蔗糖梯度沉降法对检出烷化剂诱发的DNA损伤有足够灵敏度；碱性洗脱试验法对致癌与非致癌物质的符合率约为85％～90％。
CAS号：
性质：一种检测化学物质的短期致突变/致癌性试验方法。常用培养的哺乳动物细胞系(株)作试验用生物体，以肝微粒体酶系(S9组分)作为活化系统。在合适的剂量(浓度)范围内，于二氧化碳孵化箱培养条件下进行试验。多应用同位素示踪法显示，主要检出DNA损伤后生成的单链断裂。其标准化方法有碱性蔗糖梯度沉降法和碱性洗脱法检出单链断裂，作为DNA损伤的判断。碱性蔗糖梯度沉降法对检出烷化剂诱发的DNA损伤有足够灵敏度；碱性洗脱试验法对致癌与非致癌物质的符合率约为85％～90％。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条