1) DNA replication and damage repair genes
DNA复制及损伤修复基因
1.
cDNA microarray to identify the significance of DNA replication and damage repair genes associated with benzene poisoning;
用cDNA微列阵技术探讨苯中毒相关的DNA复制及损伤修复基因表达谱的改变
2) DNA damage repair gene
DNA损伤修复基因
1.
Multiple myeloma (MM) is an incurable disease now, to which increasing DNA damage repair gene expression, increasing tumor cell drug resistance, and decreasing tumor cell apoptosis may contribute much.
目前,多发性骨髓瘤(MM)仍是一种不可治愈的疾病,其中重要的原因是MM细胞DNA损伤修复基因表达上调,导致其耐药增加,细胞凋亡减少。
3) DNA repair
DNA损伤修复
1.
To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway.
目前已经发现至少12种FA基因的缺失或突变能够引起FA表型的出现,其中10种相应的编码蛋白形成FA复合物共同参与FA/BRCA2 DNA损伤修复途径—FA途径。
2.
Previous studies show that p33 ING1b is involved in growth inhibition, apoptosis, chromatin remodeling, DNA repair, tumor suppression and cellular senescence, but its biochemical function and involvement in cellular senescence is still not fully uncharacterized.
p33ING1b是一个较晚发现的肿瘤抑制基因ING1的主要表达形式,但是它在细胞衰老过程中的作用特别是对衰老细胞DNA损伤修复的影响还没有被阐明。
3.
Objective:To establish and characterize mouse medulloblastoma(MB) cell lines with PARP-1 mutation,in order to explore the molecular machanism of MB,and to investigate the impact of PARP-1 on DNA repair proteins including Brca1、Nbs1、Ku70、Ku80 and RAD51 in the MB cells.
目的:利用PARP-1和p53基因双缺失的小鼠髓母细胞瘤细胞系,探讨DNA损伤修复因子Brca1、Nbs1、Ku70、Ku80和Rad51对小鼠髓母细胞瘤发生的意义及其相互作用关系。
4) DNA damage repair
DNA损伤修复
1.
The functions of BRCA1 and BRCA2 in DNA damage repair and transcriptional regulation;
BRCA1和BRCA2与DNA损伤修复及转录调控
2.
Cultured A-T cells lack radiation-induced cell cycle checkpoints and express cellular defects that correlate with the clinical phenotype, such as the defect of DNA damage repair capacity and a high rate of apoptosis.
人拓扑异构酶Ⅲ(human topoisomeraseⅢ，hTOP3)基因具有介导DNA损伤修复的功能。
3.
Studies on irradiation-resistant bacteria and their mechanism of DNA damage repair have been received considerable attention from the scientific community.
极端耐辐射微生物和耐辐射微生物DNA损伤修复机制研究对于环境保护和生物修复、人类健康以及生物技术创新等有着重大的理论和应用意义,是目前全球研究的热点。
5) DNA damage and repair
DNA损伤修复
1.
Establishment of thymocytes DNA damage and repair model;
MNNG诱导小鼠胸腺细胞DNA损伤修复模型的建立
2.
It formed multiple complexes with different regulatory subunits and participated in many cellular progresses such as centrosome maturation, spicesome assembly, regulation of many pathways and regulation of DNA damage and repair.
蛋白磷酸酶4(PP4或PPX)是蛋白磷酸酶2A(PP2A)家族的重要成员之一,它与多个调节亚基形成多种复合体参与诸多重要的细胞进程,如中心体的成熟、剪接体复合体的组装、多个细胞信号通路的调节以及DNA损伤修复的调节等多个事件。
3.
[Objectives] To investigate the expressions of JWA and heat shock protein 70 (hsp70) in cccHPF-1 cells after exposed to activated B(a)P, and to explore the role and the possible mechanism of JWA gene involved in B(a)P -induced DNA damage and repair.
[目的]研究苯并[a]芘[benzo(a)pyrene,B(a)P]诱导人胚肺细胞(ccc-HPF-1)DNA损伤修复中,JWA和热休克蛋白70(heat shock protein 70,hsp70)的表达规律,探讨JWA参与细胞DNA损伤修复的作用和可能机制。
6) DNA injury and DNA repair
DNA损伤与DNA修复
补充资料：复制后修复
分子式：
CAS号：
性质：又称重组修复。指DNA分子受损伤后，损伤部分的先复制后修复。例如含有嘧啶二聚体或其他结构损伤的DNA可先进行复制，但是子代DNA链在损伤的对应部位出现缺口。该缺口可通过分子间重组，从完整的母链上将相应的碱基顺序片段移至子链缺口处，然后用完整的子链作模板来补上母链的空缺，此过程即是重组修复。
CAS号：
性质：又称重组修复。指DNA分子受损伤后，损伤部分的先复制后修复。例如含有嘧啶二聚体或其他结构损伤的DNA可先进行复制，但是子代DNA链在损伤的对应部位出现缺口。该缺口可通过分子间重组，从完整的母链上将相应的碱基顺序片段移至子链缺口处，然后用完整的子链作模板来补上母链的空缺，此过程即是重组修复。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条