To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway.

Previous studies show that p33 ING1b is involved in growth inhibition, apoptosis, chromatin remodeling, DNA repair, tumor suppression and cellular senescence, but its biochemical function and involvement in cellular senescence is still not fully uncharacterized.

Objective:To establish and characterize mouse medulloblastoma(MB) cell lines with PARP-1 mutation,in order to explore the molecular machanism of MB,and to investigate the impact of PARP-1 on DNA repair proteins including Brca1、Nbs1、Ku70、Ku80 and RAD51 in the MB cells.

The functions of BRCA1 and BRCA2 in DNA damage repair and transcriptional regulation;

Cultured A-T cells lack radiation-induced cell cycle checkpoints and express cellular defects that correlate with the clinical phenotype, such as the defect of DNA damage repair capacity and a high rate of apoptosis.

Studies on irradiation-resistant bacteria and their mechanism of DNA damage repair have been received considerable attention from the scientific community.

Establishment of thymocytes DNA damage and repair model;

It formed multiple complexes with different regulatory subunits and participated in many cellular progresses such as centrosome maturation, spicesome assembly, regulation of many pathways and regulation of DNA damage and repair.

[Objectives] To investigate the expressions of JWA and heat shock protein 70 (hsp70) in cccHPF-1 cells after exposed to activated B(a)P, and to explore the role and the possible mechanism of JWA gene involved in B(a)P -induced DNA damage and repair.