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1)  Farnesoid X Receptor
类法尼醇X受体
1.
Down-regulation of Monocyte Chemoattractant Protein-1 Expression by Farnesoid X Receptor;
类法尼醇X受体下调单核细胞趋化蛋白-1表达的研究
2.
Objective:To investigate the changes of cholesterol 7alpha-hydroxylase(CYP7A1),farnesoid X receptor(FXR),and small heterodimer partner(SHP) expression in liver tissues of bile duct ligated(BDL) rats,and to analyze the relationship between their expression.
目的:通过建立梗阻性黄疸动物模型,观察胆固醇7α-羟化酶(cholesterol 7alpha-hydroxylase,CYP7A1)、类法尼醇X受体(farnesoid Xreceptor,FXR)及小异源二聚体伴侣受体(small heterodi mer partner,SHP)的表达变化,并分析CYP7A1和FXR、SHP之间的关系。
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2)  farnesoid X receptor
法尼醇X受体
1.
AIM To compare the effects of the potent endogenous farnesoid X receptor(FXR)ligand—chenodeoxycholic acid(CDCA)with ursodeoxycholic acid(UDCA)on biochemical index,hepatic histology, and fatal prognosis in rats with intrahepatic cholestasis of pregnancy(ICP).
目的以熊去氧胆酸(UDCA)为对比,研究法尼醇X受体(FXR)激动剂——鹅去氧胆酸(CDCA)对妊娠期肝内胆汁淤积(ICP)孕鼠血生化指标、肝脏病理及胎鼠预后的影响。
2.
OBJECTIVE: To compare the effect and investigate the mechanism of potent farnesoid X receptor (FXR) ligand-chenodeoxycholic acid(CDCA) with ursodeoxycholic acid(UDCA) on metabolism of bile acid in rats with estrogen-induced intrahepatic cholestasis of pregnancy(ICP).
目的:以熊去氧胆酸(UDCA)为对比,研究法尼醇X受体(FXR)强激动剂——鹅去氧胆酸(CDCA)对妊娠期肝内胆汁淤积(ICP)大鼠胆汁酸代谢的影响及其分子机制。
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3)  Farnesoid X receptor
法尼醇受体
1.
Objective: To explore the mechanism of Farnesoid X receptor(FXR) in ICP enterohepatic circulation by detecting the expression of farnesoid X receptor(FXR) and IBABP in ileum from SD rat model of ICP induced by estradiol benzoate(EB).
目的:通过苯甲酸雌二醇诱导建立孕鼠妊娠期肝内胆汁淤积症(intrahepatic cholestasis ofpregnancy,ICP)模型,检测法尼醇受体(farnesoid X receptor,FXR)、回肠胆汁酸结合蛋白(IBABP)在回肠上的表达,从胆汁酸肠肝循环角度探讨FXR通过IBABP在ICP中的作用机制。
2.
Objective To investigate the expressions of farnesoid X receptor(FXR)and its target gene cholesterol-7α-hydroxylase(CYP7A1)in liver of pregnant rats with intrahepatic cholestasis,and to explore the mechanism of intrahepatic cholestasis of pregnancy(ICP).
目的分析法尼醇受体(FXR)及其靶基因胆固醇7α-羟化酶(CYP7A1)在妊娠期肝内胆汁淤积症(intrahe-patic cholestasis of pregnancy,ICP)孕鼠肝脏的表达情况,探讨FXR与CYP7A1在ICP发病机制中的作用。
3.
Objective: To explore the mechanism of FXR in ICP enterohepatic circulation by building the rat model of intrahepatic cholestasis of pregnancy(ICP) induced by estradiol benzoate(EB) and detecting the expression of farnesoid X receptor(FXR) and IBABP (protein and mRNA) in ileum.
目的:本研究通过建立孕鼠妊娠期肝内胆汁淤积症模型,检测法尼醇受体(Farnesoid X receptor,FXR)、回肠胆汁酸结合蛋白(IBABP)在回肠上的表达,从胆汁酸肠肝循环角度探讨FXR通过IBABP在妊娠期肝内胆汁淤积症中的作用机制,从而明确FXR在回肠胆汁酸转运的作用机制。
4)  Retinoid X receptor
视黄醇类X受体
1.
Retinoid X receptor Agonists Inhibit High-Glucose-Induced Oxidative Stress in Human Endothelial Cells
视黄醇类X受体激动剂抑制高糖诱导内皮细胞氧化应激
2.
Retinoid X Receptor Ligands Inhibit High-Glucose-Induced Oxidative Stress by Antagonizing Rac-1 Activation in Human Endothelial Cells
视黄醇类X受体激动剂通过抑制Rac-1蛋白的激活对抗高糖诱导内皮细胞产生的氧化应激反应
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5)  The farnesoid X receptor
法尼酯X受体
1.
Objective To investigate the effect of the farnesoid X receptor on hepatic lipase expression and activity.
目的探讨法尼酯X受体(farnesoid X receptor,FXR)对肝脂酶(hepatic lipase,HL)表达及活性的影响。
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6)  Farnesoid X Receptor
法尼酯X受体
1.
Role of Farnesoid X Receptor in Regulating Lipid Metabolism;
法尼酯X受体在脂质代谢过程中的调控作用
2.
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily.
法尼酯X受体(farnesoid X receptor,FXR)因其天然配体为胆汁酸,又称为胆汁酸受体,是一种配体依赖性转录因子,属于核受体超家族的一员。
3.
Objective To investigate the effect of farnesoid X receptor(FXR) on the expression of scavenger receptor class B type I and its potential mechanism.
目的探讨法尼酯X受体(farnesoid X receptor,FXR)在肝细胞中对B类清道夫受体I(scavenger receptor class B type I,SR-BI)表达的影响及可能机制。
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补充资料：法尼醇
分子式：
CAS号：

性质：又称法尼醇，无环倍半萜醇。油状，沸点111℃(46.6Pa)，137℃(399.9Pa)。折射率1.4872。溶于大多数有机溶剂。广泛存在于多种植物挥发油中，如香茅油、橙花油、柠檬草油、玫瑰油、仙客来油、晚香玉油等。具盛甜鲜淡的花香，有蜜甜的玫瑰、铃兰气息，香气持久。由橙花椒酮经烯丙基重排而得。用于花香型、素心兰型日化香精，亦可用于食用香精起增浓、协调和稳定香气的作用。具有保幼激素功能。

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