An HPLC method for determination of five pyrimidines,such as 5-fluorouracil,5-bromouracil,5-iodouracil,sulfadiazine and sulfamethazine on diallyl trisulfide-bonded stationary phase(DTSP) was first developed by HPLC.

Recent advances in the synthesis of pyridopyrimidine analogues were reviewed in this article in- cluding pyrido[2,3-d]pyrimidine, pyrido[1,2-a]pyrimidine and pyrido[4,3-d]pyrimidine analogues with 71 references.

According to the result of biological experiments,2-(4,6-dimethoxy-pyrimidin-2-yloxy)-N-het/aryl-benzylamine derivatives were found to have the inhibiting activity of acetolactate synthase(ALS),and the relationship between these compounds and their activity was studied by 3D-QSAR:CoMFA and CoM-SIA.

Recent advances in the synthesis of thiazolopyrimidine analogues including thia- zolo[3,2-a]pyrimidine, thiazolo[4,5-d]pyrimidine, thiazolo[5,4-d]pyrimidine analogues, which are widely used in the fields of medicine and pesticide, are reviewed in this article.