1) pseudomonas aeruginosa exotoxin A translocating peptide
绿脓杆菌外毒素转位肽
2) PEA
[英][pi:] [美][pi]
绿脓杆菌外毒素A
1.
Recombination and Identification of PEA Receptor Binding Subunit Gene;
绿脓杆菌外毒素A受体结合区蛋白基因重组与鉴定
2.
Construction and Expression of PEA recA Fusion Gene of P aeruginosa;
绿脓杆菌外毒素ArecA基因的融合及融合蛋白的表达
3.
Objective:To study the immunoprotection of neutralizing monoclonal antibody against Pseduomonas- aeruginosa exotoxin A(PEA)so as to prevent and to treat the infection of Pseduomonas-aeruginosa bacillus.
目的:探讨绿脓杆菌外毒素A(PEA)中和性单克隆抗体在预防和治疗绿脓杆菌感染中的免疫保护作用。
3) PE40
绿脓杆菌外毒素
1.
Objective To amplify the gene encoding anti-carcinoembryonic antigen single-chain antibody ( CEA-ScFv), fuse with Pseudomonas aeruginosa exotoxin (PE40) gene and express in E.
目的扩增抗癌胚抗原单链抗体(CEA-ScFv),与绿脓杆菌外毒素(PE40)进行重组及原核表达,旨在进一步研究重组蛋白CEA-ScFv-PFA0的靶向抗肿瘤作用。
4) Pseudomonas aeruginosa exotoxin A
绿脓杆菌外毒素A
1.
Study of the chimeras of Pseudomonas aeruginosa exotoxin A and HSV-2-gD and its immunogenicity;
绿脓杆菌外毒素A与Ⅱ型单纯疱疹病毒糖蛋白嵌合表达质粒的构建及其免疫原性的研究
5) pseudomonas exotoxin
绿脓杆菌外毒素
1.
A Study on the Interleukin 2-Pseudomonas Exotoxin Fusion Proteins;
白细胞介素Ⅱ-绿脓杆菌外毒素融合蛋白的研究
2.
To develop a novel therapeutic agent capable of eliminating IL 15R over expressing abnormal cells, the gene coding for human IL 15 antagonist(IL 15M) was fused with a DNA fragment coding for the mutated form of Pseudomonas exotoxin, PEΔ293.
为研制特异的可消除IL 15受体阳性异常细胞的新型导向药物 ,将人IL 15拮抗剂 (IL 15M)基因片段与人工改造的绿脓杆菌外毒素 (PE)变异体 (PEΔ2 93)基因按正确的阅读框架融合 ,定向克隆在pET16b表达载体T7启动子的下游 ,得到质粒pET IL15M PEΔ2 93。
3.
The nucleotide sequence of structural gene of Pseudomonas exotoxin from PAK strain was determined, and its differences from that of PAK103 were first discovered.
对PAK株的绿脓杆菌外毒素结构基因进行全长核苷酸顺序测定时发现:来源于PA103株和PAK株的PE基因一级结构间存在差异,其中Thr~(179)(ACC)→Ala~(179)(GCC)、Ser~(515)(AGC)→Gly~(515)(GGC),并有11个同义突变,但变异并不影响白细胞介素2-绿脓杆菌外毒素融合蛋白的ADP-核糖基化活性及其细胞毒活性。
6) Pseudomonas exotoxin A
绿脓杆菌外毒素
1.
These constructs involved wild type caspase 3 (wt casp3), recombinant caspase 3 (r casp3) in which the order of the small and large subunits was reversed in contrast to the original protein, and chimeric recombinant (cr casp3) in which a Pseudomonas exotoxin A (PE) derived peptide was fused to N terminus of r casp3.
通过稳定转染人宫颈癌HeLa细胞 ,建立了野生型caspase 3(wt casp3) ,大小亚基序列颠倒的重组caspase 3(r casp3) ,和N端融合绿脓杆菌外毒素 (PE)转膜肽段的嵌合重组caspase 3(cr casp3)的诱导表达细胞系 。
补充资料:绿脓杆菌肺炎
绿脓杆菌肺炎
pseudomonas aeruginosa pnenmonia
一种坏死性支气管肺炎,多发生于心肺等严重病症患儿、早产儿、粒性白细胞缺乏或免疫缺陷的患儿,以及长期用抗生素治疗的患儿。临床特点:①出现寒战、中等度发热,早晨比下午高,中毒症状、咳嗽、呼吸困难和发绀;②排出大量脓性绿色痰液,可有咯血;③脉搏与体温比较相对缓慢;④肺部体征无明显的大片实化,有弥漫细湿■音及喘鸣音;⑤轻度白细胞增高,但1/3病人白细胞可减少,并可见贫血及黄疸;⑥X线胸片可见结节状浸润阴影及许多细小脓肿,后可融合成大脓肿;一侧或双侧出现少量血性胸腔积液或脓胸。⑦痰内可见大量革兰染色阴性杆菌。病情发展迅速,病死率极高,达40%。因细菌多而耐药,疗效差,近年多选用羧苄青霉素、磺苄青霉素、庆大及丁胺卡那霉素。近年来采用三代头孢菌素如头孢胺噻肟(复达新)有效。
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参考词条