Recombination and Identification of PEA Receptor Binding Subunit Gene;

Construction and Expression of PEA recA Fusion Gene of P aeruginosa;

Objective:To study the immunoprotection of neutralizing monoclonal antibody against Pseduomonas- aeruginosa exotoxin A(PEA)so as to prevent and to treat the infection of Pseduomonas-aeruginosa bacillus.

Objective To amplify the gene encoding anti-carcinoembryonic antigen single-chain antibody ( CEA-ScFv), fuse with Pseudomonas aeruginosa exotoxin (PE40) gene and express in E.

Study of the chimeras of Pseudomonas aeruginosa exotoxin A and HSV-2-gD and its immunogenicity;

A Study on the Interleukin 2-Pseudomonas Exotoxin Fusion Proteins;

To develop a novel therapeutic agent capable of eliminating IL 15R over expressing abnormal cells, the gene coding for human IL 15 antagonist(IL 15M) was fused with a DNA fragment coding for the mutated form of Pseudomonas exotoxin, PEΔ293.

The nucleotide sequence of structural gene of Pseudomonas exotoxin from PAK strain was determined, and its differences from that of PAK103 were first discovered.

These constructs involved wild type caspase 3 (wt casp3), recombinant caspase 3 (r casp3) in which the order of the small and large subunits was reversed in contrast to the original protein, and chimeric recombinant (cr casp3) in which a Pseudomonas exotoxin A (PE) derived peptide was fused to N terminus of r casp3.