1) Secretase
分泌酶
1.
Advances in Aβ-Related Secretases and Drug Design in the Therapy of Alzheimer s Disease;
与Aβ相关的分泌酶及其在药物设计中的意义
2) β-secretase
β-分泌酶
1.
β-secretase Interracts with Divalent Cation Tolerant Protein CUTA;
β-分泌酶与二价阳离子耐受蛋白CUTA存在相互作用
2.
The effect of TO901317 on the expression of β-secretase and β-amyloid peptide in hippocampal neuron;
TO901317对海马神经元β-分泌酶表达及β-淀粉样肽生成的影响
3.
Cerebral ischemia injury-induced β-amyloid formation in astrocytes associated with increases of β-secretase in rat brain;
大鼠缺血性脑损伤致星形神经胶质细胞内β-淀粉样蛋白聚集与β-分泌酶增加相关
3) γ-secretase
γ分泌酶
1.
Assembly of γ-secretase for production of β-amyloid;
催化淀粉样蛋白产生的γ分泌酶的组装
2.
Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).
膜蛋白presenilin1(PS1)是γ分泌酶的催化组分,是催化产生β淀粉样蛋白(β-amyloid,Aβ)的关键蛋白酶,因此也是治疗阿尔茨海默病(Alzheimer’s disease,AD)的主要靶点。
3.
Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.
处理超表达组(T)和对照组(C)细胞,并收集纯化过程中含γ分泌酶复合物的样本,用Western blotting检测γ分泌酶复合物重要组分Nicastrin(NCT)、Presenilin-1(PS-1)以及TMP21的蛋白表达量。
4) β-secretase
β分泌酶
1.
A screen assay of β-secretase inhibitors in vitro;
β分泌酶抑制剂体外筛选模型的构建与验证
2.
Construction and identification of RNA interfering vector targeting β-secretase;
靶向β分泌酶RNA干扰质粒的构建与鉴定
3.
New development of β-secretase;
酶解淀粉样前体蛋白的β分泌酶研究进展
5) γ-secretase
γ-分泌酶
1.
Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;
利用Gal4/VP16-UAS和双荧光素酶报告基因系统检测γ-分泌酶活性
2.
Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;
γ-分泌酶组分基因APH-1A和PEN-2的转录调控
3.
Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.
Aβ是由淀粉样前体蛋白(amyloid precursor protein,APP)经β-分泌酶(BACE)和γ-分泌酶水解产生的,因此BACE1在AD的形成过程中发挥重要作用。
补充资料：人的内分泌系统人体主要内分泌腺
李瑞端绘
[图]
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条