Objective To investigate the effects of Chinese herb compound Shen-wu capsule on the metabolism of β-amyloid(Aβ) and β-and γ-secretase in β-amyloid precursor protein(APP) transgenic mice.

Assembly of γ-secretase for production of β-amyloid;

Integral membrane protein presenilin 1(PS1) represents the catalytic component of γ-secretase, and is the crucial protease in the production of β-amyloid (Aβ).

Objective Previous studies have revealed that γ-secretase is involved in the pathogenesis of Alzheimer\'s disease.

Applying Gal4/VP16-UAS and Dual-Luciferase reporter gene system to detecting the activity of γ-secretase;

Transcriptional Regulation of APH-1A and PEN-2, Two Key Components of γ-secretase Complex;

Aβ is derived from β-amyloid precursor protein (APP) through sequential proteolytic cleavages by β-secretase (BACE1) and γ-secretase.

β-secretase Interracts with Divalent Cation Tolerant Protein CUTA;

The effect of TO901317 on the expression of β-secretase and β-amyloid peptide in hippocampal neuron;

Cerebral ischemia injury-induced β-amyloid formation in astrocytes associated with increases of β-secretase in rat brain;

A screen assay of β-secretase inhibitors in vitro;

Construction and identification of RNA interfering vector targeting β-secretase;

New development of β-secretase;