1) sulfonylurea receptor
磺脲类药物受体
1.
Objective To investigate the association between a missense mutation (T/G, Ser 1369 Ala) in exon 33 of sulfonylurea receptor 1(SUR1) gene in type 2 diabetes patients and the glucose-lowering effect of Gliclazide.
目的观察磺脲类药物受体基因(sulfonylurea receptorSUR1)第33号外显子上的一处错义突变(Ser1369Ala,TCC→GCC)与格列齐特降糖效果之间的关系。
3) sulphonylurea receptor
磺脲类受体
1.
We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) and opener (diazoxide) of ATP-sensitive potassium channels on the expression of SUR2 mRNA in preadipocytes by real-time PCR.
为了探讨ATP敏感钾通道在前脂肪细胞增殖分化中作用,本实验用逆转录实时定量PCR方法检测大鼠前脂肪细胞和诱导5 d获得的脂肪细胞中该通道磺脲类受体2(sulphonylurea receptor 2,SUR2)mRNA表达,探讨该通道阻滞剂格列本脲和激动剂二氮嗪对前脂肪细胞中SUR2 mRNA表达的影响;MTT检测前脂肪细胞增殖;流式细胞仪检测细胞周期;油红O染色法检测细胞内脂质含量;Image-Pro Plus 5。
2.
Methods: We discriminated the subtype of sulphonylurea receptor (SUR) mRNA, which is the receptor of ATP-sensitive potassium channels, in brain and adipose tissue, preadipocytes and adipocytes obtained by inducing for 5 days of rat.
方法:逆转录PCR检测大鼠脑组织、脂肪组织、前脂肪细胞和诱导5天获得的脂肪细胞中ATP敏感性钾通道磺脲类受体mRNA (SURmRNA)亚型,实时定量PCR检测前脂肪细胞和诱导5天获得的脂肪细胞中SURmRNA表达;ATP敏感性钾通道阻滞剂格列本脲和激动剂二氮嗪作用于前脂肪细胞,实时定量PCR检测SURmRNA表达,MTT检测前脂肪细胞增殖,流式细胞仪检测细胞周期分布;油红O染色法检测细胞内脂质含量,Image-Pro plus5。
4) sulfonylureas
磺脲类药物
1.
Influence of sulfonylureas on cardiovascular system:progress in basic research and clinical research;
磺脲类药物对心血管系统影响的基础和临床研究进展
2.
Effect of novolin for patients with 2-DM by sulfonylureas failure;
诺和灵治疗磺脲类药物继发性失效疗效观察
3.
OBJECTIVE In order to know if sulfonylureas have adverse effects on the cardiolvascular system, we took healthy Newsland white rabbits and observed the effects of glibenclamide, glimepiride and glipizide on the protection from myocardial ischemic preconditioning(IPC).
目的 为了研究磺脲类药物对心肌缺血方面的作用，我们选取格列本脲、格列美脲、格列吡嗪等磺脲类药物，来了解这些药物对健康新西兰白兔心肌缺血预适应的影响。
5) sulfonylurea
[英][,sʌlfənil'juəriə] [美][,sʌlfənɪljʊ'riə]
磺脲类药物
1.
Intensive therapy of continuous subcutaneous insulin infusion on diabetics with secondary sulfonylurea failure;
磺脲类药物继发性失效患者短期胰岛素泵强化治疗的临床观察
2.
AIM: To investigate the characteristics of expression and regional distribution of 2 subtypes of sulfonylurea receptors (SUR1 and SUR2) in the heart of immature and adult normal rat.
目的 :探索磺脲类药物受体 (SUR)亚型 SUR1和 SU R2在仔鼠及成年正常大鼠心肌中的定位、分布及表达特征。
3.
Objective: To compare the effect of different sulfonylureas(glibenclamide, glimepirde,gliclamide and glipizide) on the isolated rat heart myocardial protection afforded byischemic preconditioning, and observe their inhibition of ATP-sensitve potassiumcurrent of rat myocyte.
目的对比不同磺脲类药物：格列本脲、格列美脲、格列奇特和格列吡嗪对大鼠离体心脏心肌预缺血保护作用的影响，并观察它们对大鼠心肌细胞ATP依赖性钾通道电流的作用，为临床选择磺脲类药物提供参考。
6) sulfaurea drugs
磺脲类药物
1.
The efficacy of glipizide XL in the treatment of type 2 diabetic patients unresponding to sulfaurea drugs;
格列吡嗪控释片对磺脲类药物疗效不佳的2型糖尿病患者的疗效观察
补充资料：药物-受体复合体
分子式：
CAS号：
性质：机体某特定部位的受体(receptor)可选择性地与某药物分子结合而产生效应，该结合体为药物-受体复合体。其最简单的双分子反应式为A+RFRA→效应。式中A为药物分子，R为受体，RA为药物—受体复合体。
CAS号：
性质：机体某特定部位的受体(receptor)可选择性地与某药物分子结合而产生效应，该结合体为药物-受体复合体。其最简单的双分子反应式为A+RFRA→效应。式中A为药物分子，R为受体，RA为药物—受体复合体。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条