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1)  p38 regulated/activated protein kinase
p38调节/激活蛋白激酶
1.
Objective: To construct eukaryotic cell expression vectors of different p38 regulated/activated protein kinase(PRAK) mutants fused with enhanced green fluorescent protein(EGFP) and to study the intracellular localizations of the recombinant mutant proteins.
目的:构建p38调节/激活蛋白激酶(PRAK)不同突变体的绿色荧光蛋白融合表达载体,并在真核细胞中表达后,观察这些突变体在细胞内的定位情况。
2)  p38 regulated activated protein kinase
p38调节活化蛋白激酶(PRAK)
3)  p38 regulated/activated protein kinase (PRAK)
p38调节活化蛋白激酶
4)  p38 mitogen-activated protein kinase
p38丝裂原激活蛋白激酶
1.
Objective:To identify the role of p38 mitogen-activated protein kinase(p38 MAPK)and its specific inhibitor,SB203580,in airway inflammation and mucus hypersecretion in vivo.
目的探讨小鼠吸入丙烯醛后是否出现气道黏液高分泌及其产生机制,观察p38丝裂原激活蛋白激酶(p38MAPK)信号通路在气道炎症损伤、黏液高分泌中的作用,以及应用p38MAPK特异性抑制剂SB203580干预后对气道炎症、MUC5AC的影响。
2.
Objective: To investigate the effects of pentoxifylline (PTX) on activation of p38 Mitogen-activated protein kinase, and to study the protective mechanism of PTX on endothel cell monolayer permeability.
目的:观察己酮可可碱(PTX)对p38丝裂原激活蛋白激酶(MAPK)激活的影响,探讨PTX保护内皮细胞单层通透性的机制。
3.
Though there was one literature about p38 mitogen-activated protein kinase(MAPK) involed in regulation of LPS-induceed ICAM- 1 protein.
尽管已有文献报道p38丝裂原激活蛋白激酶(MAPK)可能参与LPS诱导内皮细胞ICAM-1蛋白的表达,但仍不清楚p38MAPK作用的位点是在ICAM-1蛋白翻译水平或是在基因转录水平。
5)  p38MAPK
p38丝裂原激活蛋白激酶
1.
OBJECTIVE To investigate the effect of astilbin on activation of p38 mitogen activated protein kinase(p38MAPK) in activated T cells of mouse heart transplantation model with acute rejection.
目的:用小鼠心脏移植急性排斥反应体外模型,探讨落新妇苷对心脏移植排斥反应中活化T细胞p38丝裂原激活蛋白激酶(p38MAPK)信号传导通路的影响。
2.
This article was presented to study the effects of tetrandrine(Tet) on phenotypic modulation of vascular smooth muscle cells(VSMC) and p38 mitogen-activated protein kinase(p38MAPK) as well as mitogen-activated protein kinase phosphotase-1(MKP1) after vascular intimal injury.
研究粉防己碱(tetrandrine,Tet)抑制内膜损伤后血管平滑肌细胞(VSMC)表型转化和对p38丝裂原激活蛋白激酶(p38MAPK)及丝裂原激活蛋白激酶磷酸酶-1(MKP-1)表达的影响。
6)  p38 MAPK
p38丝裂原激活蛋白激酶
1.
[Objectives] To clarify the effect of p38 MAPK on airway inflammation and mucus hypersecretion and the possible cross-talk between p38 MAPK and MMP-9 in mucin gene transcription.
[目的]探讨p38丝裂原激活蛋白激酶(p38 MAPK)信号通路及其特异性抑制剂SB203580在气道炎症、黏液高分泌中的作用,阐明p38MAPK、基质金属蛋白酶-9(MMP-9)在黏液高分泌与黏蛋白基因转录中的相互作用机制。
2.
Objective To investigate the expression of phosphorylated p38 mitogen activated protein kinase(p-p38 MAPK) and protein expression levels at different ischemic time point in focal cerebral ischemic core and penumbra of rats.
目的研究大鼠局灶性脑缺血不同缺血时间皮质半暗带和中心区p38丝裂原激活蛋白激酶(p38 MAPK)磷酸化水平和蛋白水平的表达。
3.
Objective To explore the effect of hypoxic preconditioning(HPC) on middle cerebral artery occlusion(MCAO)-induced brain injury of mice and the changes of P38 mitogen activated protein kinase(P38 MAPK) phosphorylation and protein expression levels in the ischemic cortex.
目的探讨P38丝裂原激活蛋白激酶(P38 MAPK)磷酸化和蛋白表达水平在低氧预适应(HPC)降低脑中动脉阻塞(MCAO)所致缺血性脑损伤中的变化。
补充资料:蛋白激酶A
分子式:
CAS号:

性质:一种依赖cAMP的蛋白激酶。它由4个亚基组成,2个相同的调节亚基(R)和2个相同的催化亚基(C)。有两种同酶形式,I型和Ⅱ型,它们之间的催化亚基相同而调节亚基不同。四聚体全酶(R2C2)处于无活性状态,当4分子cAMP结合到两个调节亚基的结合部位时,无活性的四聚体介离,产生具有酶活性的游离催化亚基以及调节亚基与cAMP的复合物(R-cAMP)。PKA的作用底物包括膜蛋白、胞浆蛋白和核内蛋白,使多种蛋白质的丝氨酸或苏氨酸羟基的磷酸化,并由此引起一系列生化反应。

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