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1)  P38MAPK
P38蛋白激酶
1.
Aim:To observe the expression of P38MAPK and JNKMAPK in cultured neutrophils induced by LPS, and study the regulative mechanism.
目的:观察体外培养大鼠中性粒细胞经细菌脂多糖(LPS)刺激后P38蛋白激酶和JNK蛋白激酶的变化,并探讨其调节作用。
2.
Then the intervened groups were intraperitoneally injected with the p38MAPK inhibitor SB203580 and nuclear factor kappa B(NF-κB) inhibitor PDTC,respectively.
04mL)的肺炎衣原体鼻内接种,SB203580组和PDTC组在接种完肺炎衣原体后分别立即腹腔注射相应的p38蛋白激酶(p38MAPK)抑制剂SB203580(100mg/kg)或核因子κB(NF-κB)抑制剂吡咯烷二硫氨基甲酸(PDTC)(50mg/kg)。
2)  p38 mitogen-activated protein kinase
p38蛋白激酶
1.
Objective To explore the role of p38 mitogen-activated protein kinase(MAPK) in the activation of nuclear factor-κB(NF-κB) in lipopolysaccharide(LPS)-stimulated alveolar macrophages(AMs).
目的探讨p38蛋白激酶对脂多糖(LPS)诱导肺泡巨噬细胞NF-κB活化的调控机制。
2.
Objective To explore the role of P38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) in the expression of inducible nitric-oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated alveolar macrophages (AMs).
目的 探讨P38蛋白激酶和核因子κB (NF κB) 在脂多糖(LPS) 诱导肺泡巨噬细胞诱生型一氧化氮合酶(iNOS) 表达过程中的调控作用。
3)  protein kinase p38
蛋白激酶p38
4)  p38 MAP kinase
p38蛋白激酶
1.
p38 MAP kinase (p38 MAPK) plays a role in cell proliferation, survival and apoptosis.
而p38蛋白激酶(p38 MAP kinase, p38MAPK)为丝裂原活化蛋白激酶(mitogen activated protein kinase, MAPK)信号通路三个主要的亚家族之一,与细胞增殖、存活和凋亡密切相关。
5)  p38 mitogen-activated protein kinase
p38丝裂原激活蛋白激酶
1.
Objective:To identify the role of p38 mitogen-activated protein kinase(p38 MAPK)and its specific inhibitor,SB203580,in airway inflammation and mucus hypersecretion in vivo.
目的探讨小鼠吸入丙烯醛后是否出现气道黏液高分泌及其产生机制,观察p38丝裂原激活蛋白激酶(p38MAPK)信号通路在气道炎症损伤、黏液高分泌中的作用,以及应用p38MAPK特异性抑制剂SB203580干预后对气道炎症、MUC5AC的影响。
2.
Objective: To investigate the effects of pentoxifylline (PTX) on activation of p38 Mitogen-activated protein kinase, and to study the protective mechanism of PTX on endothel cell monolayer permeability.
目的:观察己酮可可碱(PTX)对p38丝裂原激活蛋白激酶(MAPK)激活的影响,探讨PTX保护内皮细胞单层通透性的机制。
3.
Though there was one literature about p38 mitogen-activated protein kinase(MAPK) involed in regulation of LPS-induceed ICAM- 1 protein.
尽管已有文献报道p38丝裂原激活蛋白激酶(MAPK)可能参与LPS诱导内皮细胞ICAM-1蛋白的表达,但仍不清楚p38MAPK作用的位点是在ICAM-1蛋白翻译水平或是在基因转录水平。
6)  p38 regulated/activated protein kinase
p38调节/激活蛋白激酶
1.
Objective: To construct eukaryotic cell expression vectors of different p38 regulated/activated protein kinase(PRAK) mutants fused with enhanced green fluorescent protein(EGFP) and to study the intracellular localizations of the recombinant mutant proteins.
目的:构建p38调节/激活蛋白激酶(PRAK)不同突变体的绿色荧光蛋白融合表达载体,并在真核细胞中表达后,观察这些突变体在细胞内的定位情况。
补充资料:蛋白激酶A
分子式:
CAS号:

性质:一种依赖cAMP的蛋白激酶。它由4个亚基组成,2个相同的调节亚基(R)和2个相同的催化亚基(C)。有两种同酶形式,I型和Ⅱ型,它们之间的催化亚基相同而调节亚基不同。四聚体全酶(R2C2)处于无活性状态,当4分子cAMP结合到两个调节亚基的结合部位时,无活性的四聚体介离,产生具有酶活性的游离催化亚基以及调节亚基与cAMP的复合物(R-cAMP)。PKA的作用底物包括膜蛋白、胞浆蛋白和核内蛋白,使多种蛋白质的丝氨酸或苏氨酸羟基的磷酸化,并由此引起一系列生化反应。

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