1) oncolytic adenovirus
溶瘤腺病毒
1.
Effects of oncolytic adenovirus H101 treatment on tumor tissue of nude mice transplanted with human esophageal carcinoma cells induced by carcinoembryonic antigen gene silencing
癌胚抗原基因抑制对溶瘤腺病毒H101治疗人食管癌裸鼠皮下移植瘤的影响
2.
To reduce the killing effect of oncolytic adenovirus on normal cells and get safe clinical application,oncolytic adenovirus AdCN103,a novel dual-targeting tumor specific proliferating virus,was constructed by replacing the wild type adenovirus E1A promoter with the promoter of human telomerase reverse transonptase(hTERT) and mutant E1A lacking CR2 region.
为了降低溶瘤腺病毒对正常细胞的杀伤作用,提高临床应用上的安全性,构建了一种双靶向溶瘤增殖型腺病毒AdCN103,以人端粒酶逆转录酶(hTERT)启动子代替野生型腺病毒E1A自身的启动子,同时在E1A区缺失保守区域CR2的24bp。
3.
To develop a novel gene therapeutic oncolytic adenovirus in which the hTERT promoter was introduced and used to regulate adenoviral E1A gene.
为构建一种由人端粒酶逆转录酶启动子(hTERTp)调控的能够在肿瘤细胞中特异性增殖的新型肿瘤基因治疗溶瘤腺病毒载体系统,利用基因重组技术将hTERTp插入5型腺病毒E1A基因上游,构建肿瘤特异性增殖腺病毒AdSU,使其携带绿色荧光蛋白报告基因。
2) HCC-specific CRAd
溶瘤性腺病毒
3) oncolytic adenovirus vector
溶瘤腺病毒载体
1.
With the development of gene-virotherapy for cancer, more and more tumor-specific promoters are employed to mediated oncolytic adenovirus vector for tumor selective cytotoxicity.
肿瘤特异性启动子用于调控溶瘤腺病毒载体靶向于肿瘤细胞,从而实现对肿瘤组织的特异性杀伤,肿瘤特异性启动子的应用已成为靶向基因病毒治疗中的一个重要策略。
4) Bicistronic adenovirus
双顺反子溶瘤腺病毒
5) replicative oncolyitc adenovirus
增殖性溶瘤腺病毒
1.
ZD55-IL-24 is a replicative oncolyitc adenovirus carrying tumor-specific interleukin-24 gene and targeting tumor cells with loss of p53.
增殖性溶瘤腺病毒ZD55-IL-24是靶向p53缺失且携带肿瘤特异性的白细胞介素-24基因(IL-24);丝裂霉素(mitomycin C,MMC)是一种目前临床上癌症治疗常用化疗药物之一。
6) Oncolytic virus
溶瘤病毒
1.
Oncolytic virus is a kind of virus killing tumor cells with duplication ability,which can duplicate in tumor cells depending on its own specificity and then kill and split the tumor cells.
溶瘤病毒是一类具有复制能力的肿瘤杀伤型病毒。
2.
Objective:To observe the effectiveness of oncolytic virus H101 combined with chemotherapy in treatment of patients with lymph node metastasis of nasopharyngeal carcinoma, and to discuss the related mechanism.
目的:观察溶瘤病毒药物H101联合化疗药物对鼻咽癌淋巴结转移的治疗效果,初步探讨H101的作用机制。
补充资料：促肾上腺皮质激素腺瘤
促肾上腺皮质激素腺瘤
ACTH secreting adenoma,Cushing disease
分泌过多的ACTH导致肾上腺皮质增生而分泌过量的糖皮质激素，造成多种物质代谢紊乱及抵抗力降低，即皮质醇增多症，临床表现为身体向心性肥胖，满月脸、水牛背，多血质、腹部和大腿皮肤有紫纹，毳毛增多等，重者闭经、性欲减退、全身乏力。有的并有高血压、糖尿病等，本症应与其他原因所引起的皮质醇增多症(cushing syndrome)相鉴别，少数肥胖病患者亦可有类似的皮质醇增多的症状，测血浆ACTH及地塞米松试验有助于鉴别诊断。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条