2) Oncolytic virus
溶瘤病毒
1.
Oncolytic virus is a kind of virus killing tumor cells with duplication ability,which can duplicate in tumor cells depending on its own specificity and then kill and split the tumor cells.
溶瘤病毒是一类具有复制能力的肿瘤杀伤型病毒。
2.
Objective:To observe the effectiveness of oncolytic virus H101 combined with chemotherapy in treatment of patients with lymph node metastasis of nasopharyngeal carcinoma, and to discuss the related mechanism.
目的:观察溶瘤病毒药物H101联合化疗药物对鼻咽癌淋巴结转移的治疗效果,初步探讨H101的作用机制。
3) oncolytic adenovirus
溶瘤病毒
1.
Telomerase-dependent oncolytic adenovirus for cancer treatment;
端粒酶为靶点的溶瘤病毒的抗肿瘤作用研究
2.
Infection of tumor cells with oncolytic adenovirus results in tumor-specific replication, subsequent oncolysis and release of the virus progeny.
增殖型腺病毒又称条件复制型腺病毒或溶瘤病毒,可利用肿瘤与正常组织细胞间结构及代谢途径的差异,靶向性地在肿瘤细胞内复制增殖,最终裂解肿瘤细胞,同时能长效表达抗肿瘤的外源基因。
4) oncolytic viruses
溶瘤病毒
1.
Thirty-six journals about oncolytic viruses were found.
利用中国生物医学文献数据库,采用文献计量法,分析1978～2006年我国溶瘤病毒学研究文献的年发文量、合作度、合作率、期刊及地域分布、基金支持等指标和内容。
5) oncolytic adenovirus
溶瘤腺病毒
1.
Effects of oncolytic adenovirus H101 treatment on tumor tissue of nude mice transplanted with human esophageal carcinoma cells induced by carcinoembryonic antigen gene silencing
癌胚抗原基因抑制对溶瘤腺病毒H101治疗人食管癌裸鼠皮下移植瘤的影响
2.
To reduce the killing effect of oncolytic adenovirus on normal cells and get safe clinical application,oncolytic adenovirus AdCN103,a novel dual-targeting tumor specific proliferating virus,was constructed by replacing the wild type adenovirus E1A promoter with the promoter of human telomerase reverse transonptase(hTERT) and mutant E1A lacking CR2 region.
为了降低溶瘤腺病毒对正常细胞的杀伤作用,提高临床应用上的安全性,构建了一种双靶向溶瘤增殖型腺病毒AdCN103,以人端粒酶逆转录酶(hTERT)启动子代替野生型腺病毒E1A自身的启动子,同时在E1A区缺失保守区域CR2的24bp。
3.
To develop a novel gene therapeutic oncolytic adenovirus in which the hTERT promoter was introduced and used to regulate adenoviral E1A gene.
为构建一种由人端粒酶逆转录酶启动子(hTERTp)调控的能够在肿瘤细胞中特异性增殖的新型肿瘤基因治疗溶瘤腺病毒载体系统,利用基因重组技术将hTERTp插入5型腺病毒E1A基因上游,构建肿瘤特异性增殖腺病毒AdSU,使其携带绿色荧光蛋白报告基因。
6) HCC-specific CRAd
溶瘤性腺病毒
补充资料：病毒致瘤
病毒致瘤
viral induced tumor
诱发肿瘤的病毒可分为核糖核酸(RNA)肿瘤病毒和脱氧核糖核酸(DNA)肿瘤病毒两大类。由于致癌性PNA病毒含有逆转录酶，又称为逆转录病毒。多瘤病毒SV40和兔乳头状瘤病毒的DNA在动物体内可诱发肿瘤。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条