Preparation of oxytetracycline hydrochloride containing polylactic acid by water-in-oil and drug-relaeasing performance;

Some factors which affected the water-in-oil emulsion were inspected by test the outward appearance,kin feeling as well as the ability of cold-resisting and heat-resisting of the water-in-oil emulsion in the paper.

A study of the carrier technology and stability of water-in-oil-in-water multiple emulsions (W/OAV);

Therefore,using S/W/O/W method and adding additives HAP and HPB in the formulation could decrease the initial burst release of drugs from the microspheres and increase the encapsulation capacity of the BSA-PLG microspheres,the in-vitro release profiles of which were fitted into near zero order release kinetics.

The results studied by dilution method showed that a part of n-hexanol in n-heptane together with surfactant constructed a mixed film,which improved the molecular geometry of the mixed components and resulted in the formation of W/O microemulsion.

The states of water in the W/O microemulsions formed in H2O/C12-EOx-C12·2Br/n-hexanol/ n-heptane systems have been investigated by Fourier transform infrared spectroscopy(FT-IR).

Effects of W/O microemulsions on pharmacokinetics after intraduodenal administration, membrane fluidity and membrane transport of Rb_1 were studied in rats, liposomes and parallel artificial membrane permeability assay (PAMPA), respectively.