1) asymmetric dihydroxylation
不对称双羟基化反应
1.
N,N'-Diferrocenylmethyl-(1S,2S)-1,2-diphenylethanediamine was synthesized by two steps from (1S,2S)-1,2-diphenylethanediamine and ferrocenealdehyde, and has been used as chiral ligand to asymmetric dihydroxylation of olefins.
(1S,2S)-1,2-二苯基乙二胺和甲酰基二茂铁经缩合和还原两步反应,以90%的产率合成了N,N'-二茂铁甲基-(1S,2S)-1,2-二苯基乙二胺,并以其为配体催化烯烃的不对称双羟基化反应,获得了较高的对映选择性(71%～86%ee)。
2) asymmetric dihydroxylation
不对称双羟化反应
1.
Synthesis of quinine and cinchonine derivatives and their catalytic performance in asymmetric dihydroxylation;
奎宁和辛可宁衍生物的合成及其在不对称双羟化反应中的催化作用
2.
Application of the ligand-OsO_4 in the asymmetric dihydroxylation reaction of several olefins afforded corresponding chiral diols in yield of 91%～94% and 93% e.
OsO4-2用于催化烯烃的不对称双羟化反应,化学产率91%~94%,e。
3.
METHODS The C13 side chain of the taxol was synthesized via asymmetric dihydroxylation of trans-cinnamate,which was catalyzed by a kind of free recoverable and resued chiral ligand and OsO4.
方法在可回收非支载型手性配体的催化作用下,通过不对称双羟化反应合成紫杉醇C13侧链,对侧链的羟基和氨基进行保护后生成(4S,5R)-N-苯甲酰基-2-(4′-甲氧基)苯基-4-苯基-1,3-氧氮杂戊环-5-甲酸,进而和7-三乙基硅烷巴卡亭-Ⅲ缩合、去保护获得紫杉醇。
3) asymmetric dihydroxylation(AD)
不对称双羟化反应(AD)
4) Sharpless asymmetric dihydroxylation
Sharpless不对称双羟化反应
6) asymmetric aminohydroxylation
不对称氨羟化反应
1.
Novel semisynthetic method of paclitaxel via asymmetric aminohydroxylation;
不对称氨羟化反应合成抗癌药物紫杉醇
2.
In the presence of benzyl N-chlorocarbamate (the oxidant and nitrogen source), five methyl cinnamates gave the vicinal amino alcohols via asymmetric aminohydroxylation .
在氧化-供氮试剂N-氯代氨基甲酸苄酯存在下,(QN)2AQN与OsO4原位生成的催化剂在五种肉桂酸甲酯的不对称氨羟化反应中表现出优异的对映选择性(90%～96%ee)和一般至优秀的区域选择性(75∶25～98∶2),产率50%～70%,高于文献报道的结果。
补充资料：不对称羟基化
分子式：
CAS号：
性质：应用羟基化反应进行不对称合成。
CAS号：
性质：应用羟基化反应进行不对称合成。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条