Imidazo〔1,2-b〕pyridazine is the main intermediate with side chain for synthesis of cephalosporins, it has become a bottle-necking problem for development of cefozopran as its greater difficulty in synthesis.

This paper reviews the antimicrobial mechanism,antibacterial spectrum of activity against gram-positive organisms,pharmacological features and clinical indications of cefozopran as well as its clinical efficacy and safety.

6-Chloroimidazo[1,2-b]pyridazine,as an important intermediate of cefozopran,was synthesized from hydrazine hydrate and maleic anhydride through condensation,chlorination,ammonolysis and ring-closing reaction,with the total yield of 65.

In this paper,application on determination of residual solvent in medicine by wide-bore capillary HS-GC are mainly introduced,the test methods for Heparin Sodium,Xantinol Nicotinate,Fosinopril Sodium and Cefozopran Hydrochloride are established,through establishing those test method,the principl.

Determination of Cefozopran hydrochloride and its related substances in Cefozopran hydrochloride for injection by HPLC;

Combination of cefmetazole with ciprofloxacin against 33 strains of extended-spectrum beta-lactamase-resistent bacteria;

The study on the antibacterial activity of cefmetazole combined with gatifloxacin against 33 strains extended-spectrum beta-lactamase production bacteria;

Electrochemical Behavior of Degradation Product of Cefazolin with Silver Microdisk Electrode and Its Application to Analytical Chemistry;

Prophylactic Use of Cefazolin for Perioperative Infection in Gynecologic Surgery:A Randomized Controlled Study;

Simultaneous determination of cefazolin and baicalin in rabbit serum by HPLC;

Determination of Main Component in Ceftizoxime Sodium for Injection by HPLC;

Determination of Serum Ceftizoxime Concentration by HPLC;

Comparison of ceftizoxime stability with other 14 β-lactams to β-lactamases;