Effects of novel herbicide ZJ0273 on acetolactate synthase activity in oilseed rape and crickweed

Activity of acetolactate synthase as influenced by Monosulfuron was detected in vitro and in vivo using three maize cultivars that had different sensitivity to monosulfuron detected by bioassay experiment.

The inhibiting effect of the SU on acetolactate synthase activity(ALS) of SU resistant biotypes is lower than susceptive biotypes.

In order to study its mechanism of the herbicide-resistance, analytical method of in vitro was employed to evaluate the inhibitory effect of SU on the acetolactate synthases(ALS) in Monochoria korsakowii.

Chlorosulfuron is a typical acetolactate synthase (ALS) inhibitor.

It s mode of action is acetolactate synthase (ALS), because the biosynthesis of branced-chainamino acid (valine, leucine and isoleucine) and cell divison are inhibited, and lead to the growth of plant stopped.

) in vitro and in vivo in a detail ed form with a purpose to elucidate the mode of action of acetolactate synthase (ALS) inhibitors and establish a bio physiological screening model of high efficacy herbicides.

According to the result of biological experiments,2-(4,6-dimethoxy-pyrimidin-2-yloxy)-N-het/aryl-benzylamine derivatives were found to have the inhibiting activity of acetolactate synthase(ALS),and the relationship between these compounds and their activity was studied by 3D-QSAR:CoMFA and CoM-SIA.

Since the appearance of chlorimuron ethyl, the first acetohydroxyacid synthase(ALS) inhibitor in 1970s, sulfonylurea herbicides have been widely and rapidly adopted.