1) asymmetric dihydroxylation
不对称二羟化
1.
Synthesis and utilization of two novel chirl liands for asymmetric dihydroxylation;
两种不对称二羟化反应的新型手性配体的合成及其应用
2.
A novel recoverable and reusable chiral ligand for asymmetric dihydroxylation of olefins was prepared from 1,4-difluoroanthraquinone by two steps.
在不对称二羟化反应的 2种不同体系中 ,该配体对 6种烯烃的反应表现出很高的对映选择性 (80 %～97% )和催化活性 (80 %～ 94 % ) 。
3.
Ethyl trans-p-methoxycinnamate was transformed into ethyl (2R,3S)-2,3-dihydroxy-3-(4-methoxyphenyl)propionate(2) in 87% yield and 99%ee by osmium-catalyzed asymmetric dihydroxylation with 1,4-bis(9-O-quininyl)phthalazine as the chiral ligand.
以1,4-双(9-O-奎宁基)-2,3-二氮杂萘为手性配体,经锇催化的不对称二羟化反应将反式-对甲氧基肉桂酸乙酯转化为(2R,3S)-2,3-二羟基-3-(4-甲氧基苯基)丙酸乙酯(2),收率87%,ee值大于99%;2与氯化亚砜反应得到地尔硫的手性中间体(4S,5R)-4-(4-甲氧基苯基)-5-乙氧羰基-1,3-二氧杂-2-氧代硫杂环戊烷,收率85%。
2) Asymmetric dihydroxylation
不对称二羟基化
1.
METHODS The asymmetric dihydroxylations of trans stilbene, naphthyl allyl ether and styrene were catalyzed by DHQD PHAL OPEG OMe/OsO 4 with tBuOH H 2O (1∶1) as the solvent and K 3Fe(CN) 6 as the cooxidant.
方法 以 t Bu OH/H2 O(1∶1)为溶剂 ,以 K3Fe(CN ) 6 为共氧化剂 ,用 DHQD- PHAL -OPEG- OMe/Os O4 分别催化反式二苯乙烯、萘基烯丙基醚和苯乙烯的不对称二羟基化反应 。
2.
The asymmetric dihydroxylation of ortho-substituted 1,2-diphenylethenes affords the corresponding diols in good yields (77～89%) and high enantiomeric excesses (73～98%) in the presence of catalytic amount OsO4 and four different chiral ligands respectively.
邻位取代１，２－二苯乙烯催化不对称二羟基化反应张生勇，孙晓莉（第四军医大学化学教研室西安７１００３２）关键词 不对称二羟基化，手性二醇近年催化的反式稀烃的不对称二羟基化反应取得明显进展［１］，但催化的邻位取代的１，２－二苯乙烯类化合物。
3) Sharpless asymmetric dihydroxylation reaction
Sharpless不对称二羟化反应
1.
Two recyclable ligands were prepared and applied to Sharpless asymmetric dihydroxylation reaction in two solvent systems for preparation of ethyl (2R,3S)-2,3-dihydroxy-3-phenylpropionate, the C13 side chain of paclitaxel, from ethyl cinnamate.
合成了两种可回收利用的小分子配体,并在两种不同体系的Sharpless不对称二羟化反应中用于催化肉桂酸乙酯,以合成紫杉醇的重要中间体(2R,3S)-2,3-二羟基-3-苯丙酸乙酯。
4) asymmetric dihydroxylation
不对称二羟化反应
5) asymmetric dihydroxylation
不对称双羟化
1.
The use of(QD)_2 PYDZ in asymmetric dihydroxylation(AD)of olelfins provided the corresponding chiral vicinal diols with 88～95%chemical yield and the values of enantiomeric excess(ess)are between 75% and 99%.
烯烃不对称双羟化反应(Asymmetric D ihydroxylation,简称AD反应)和不对称氨羟化反应(Asymmet-ric Am inohydroxylation,简称AA反应)是获得手性连二醇和手性β-氨基醇的最简便的方法[1]。
2.
A series of enantiopure β-amino alcohols were synthesized from the corresponding diols pro- duced by Sharpless asymmetric dihydroxylation, cyclization of diols, azide opening of epoxides, and cata- lytic hydrogenation of the resulting azido alcohols.
在手性配体1,4-双(9-O-奎宁)-2,3-二氮杂萘[(QN)2PHAL]存在下,通过烯烃的Sharpless不对称双羟化、环化、亲核开环和催化氢化等步骤方便地合成了手性β-氨基醇。
3.
Moreover, the resin-bound OsO 4 exhibited excellent catalytic activity in the asymmetric dihydroxylation of olefins and was easily recovered and reused in five consecutive reactions, without significant decrease in activity.
合成了在烯烃不对称双羟化反应中可回收和重复使用的TentaGel支载的OsO4催化剂 。
6) asymmetric aminohydroxylation
不对称氨羟化
1.
The asymmetric aminohydroxylation (AA) of olefins using catalytic amounts of potassium osmate in the presence of cinchona alkaloid derivatives has become the most powerful method for the preparation of a wide variety of enantiomerically pure β-amino alcohols.
以N氯代氨基甲酸苄酯钠为氧化供氮试剂,由(DHQD)2PYDZ与OsO4原位生成的催化剂在6种烯烃的不对称氨羟化反应中表现出较高的立体选择性(83%～92%)和区域选择性(79∶21～88∶12),反应主产物的化学产率为40%～76%。
2.
The application of sharpless asymmetric aminohydroxylation reaction to a - luryl ethylene and its derivatives is described in this paper.
将Sharpless等人报道的不对称氨羟化反应方法应用于α-呋喃乙烯类化合物,并对其区域选择性进行了研究。
补充资料：甲基化-4,5-二羟基-1,3-二(羟甲基)-2-咪唑啉酮
CAS：68411-81-4
中文名称：甲基化-4,5-二羟基-1,3-二(羟甲基)-2-咪唑啉酮
英文名称：2-Imidazolidinone, 4,5-dihydroxy-1,3-bis(hydroxymethyl)-, methylated
中文名称：甲基化-4,5-二羟基-1,3-二(羟甲基)-2-咪唑啉酮
英文名称：2-Imidazolidinone, 4,5-dihydroxy-1,3-bis(hydroxymethyl)-, methylated
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
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