Objective:To further understand the clinicopathological,ultrastructural and molecular features of penile pseudoangiosarcomatous squamous cell carcinoma(PASCC),and improve its diagnosis and treatment.

Expression and significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma;

Expression of fasciclin and annexin I in the pre-malignant lesions of esophageal squamous cell carcinoma;

Loss of heterozygosity on chromosome 13q11-12 in esophageal squamous cell carcinoma;

Objectives: To investigate the clinicopathological significance of Twist-1 gene expression in esophageal squamous cell carcinoma (ESCC) by RNAi, Western blot, Real-time PCR, MS-PCR, immunohistochemical staining and other techniques.

This study was designed to investigate the correlation of SNPs, -1306C/T in the promoter region of MMP-2 and -418G/C in the promoter region of TIMP-2, to susceptibilities of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region of Hebei Province.

Aim:To study the effect of hypoxia on expression of multidrug resistance protein(MRP1) and its mechanism of multidrug resistance in ESCC, and to provide a new target for treatment of ESCC.

The introducing of foreign Notch1 can activate the Notch1 signaling pathway and give rise to the apoptosis of esophageal squamous cell carcinoma cells, suggesting that the Notch1 gene may be a new molecular target for therapy of esophageal squamous cell carcinoma.

Development of microcomputer system for SCCA marker detection;