Expression and significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma;

Expression of fasciclin and annexin I in the pre-malignant lesions of esophageal squamous cell carcinoma;

Loss of heterozygosity on chromosome 13q11-12 in esophageal squamous cell carcinoma;

Objectives: To investigate the clinicopathological significance of Twist-1 gene expression in esophageal squamous cell carcinoma (ESCC) by RNAi, Western blot, Real-time PCR, MS-PCR, immunohistochemical staining and other techniques.

This study was designed to investigate the correlation of SNPs, -1306C/T in the promoter region of MMP-2 and -418G/C in the promoter region of TIMP-2, to susceptibilities of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region of Hebei Province.

Aim:To study the effect of hypoxia on expression of multidrug resistance protein(MRP1) and its mechanism of multidrug resistance in ESCC, and to provide a new target for treatment of ESCC.

Biological Function and Molecular Mechanism of OLC1 Overexpression in Human Esophageal Squamous Cell Carcinoma (ESCC) Cells;

The introducing of foreign Notch1 can activate the Notch1 signaling pathway and give rise to the apoptosis of esophageal squamous cell carcinoma cells, suggesting that the Notch1 gene may be a new molecular target for therapy of esophageal squamous cell carcinoma.