Genetic detection and prenatal diagnosis of autosomal dominant polycystic kidney disease in a family

Objective To investigate the polymorphisms of four microsatellites,D4S1534, D4S1563,D4S423 and D4S414, which are tightly linked to polycystic kidney disease 2 (PKD2) gene, and hence to provide a basis for studying the heterogeneity of adult polycystic kidney disease (APKD).

Clinic study on 169 cases of polycystic kidney;

Expression of matrix metalloproteinases-1/tissue inhibitor of metalloproteinase-1 in kidney of patients with autosomal dominant polycystic kidney disease;

Sirolimus slows down disease progression in rats with autosomal dominant polycystic kidney disease and renal dysfunction;

Objectives To discuss clinical characteristics and early diagnosis of polycystic kidney disease (PKD) in children.

Objective:To investigate the effect of mycophenolate mofetil(MMF)on proliferation and apoptosis of cyst-lining epithelial cells in patients with autosomal dominant polycystic kidney disease(ADPKD),and to compare its effect with that of rapamycin(RAPA)in vitro.

Morphology of renal tissue in Han:SPRD,a rat model of autosomal dominant polycystic kidney disease;

Gene diagnosis of autosomal dominant polycystic kidney disease type 2 using microsatellite DNA tightly linked to polycystic kidney disease gene 2;

N-(4-hydroxyphenyl) retinamide induced apoptosis in autosomal dominant polycystic kidney disease cyst-lining epithelial cells;