In the paper, the synthesis of sulfonamide arylβ-diketo acids and quinoxalinone derivatives is the aim of our research based on the analysis priminary fact of arylβ-diketo acids HIV-1 integrase inhibitors.

Polydroxylated styrylquinoline derivatives are one of the potential HIV-1 integrase inhibitors with anti-viral activity in cell culture.

Progress on diketo acid HIV-1 integrase inhibitors

In this article,the important strategies of CADD are summarized;and the applications of CADD in the development of HIV-1 integrase inhibitors and influenza virus neuraminidase inhibitors are particularly introduced.

HIV protease inhibitors and apoptosis;

In order to develop the HIV integrase inhibitors with high bioactivity、low toxicity and favorable bioavailability, several key DKAs (Diketo acids) integrase inhibitors are introduced to provide academic basis for searching effective anti-HIV medicine according to those medicines widely used in market.

Recent developments and approaches for anti-HIV chemical drugs in clinical trials were re- viewed and analyzed in this manuscript,including new agents of entry inhibitors,reverse transcriptase inhibitors, integrase inhibitors,protease inhibitors,maturation inhibitors,zinc finger inhibitors,and so forth.

In this review,current five kinds of anti-HIV drugs including nucleotide reverse-transcriptase inhibitors(NRTIs),Non-nucleoside reverse-transcriptase inhibitors(NNRTIs),Protease inhibitors(PIs), Entry Inhibitors(EIs) and integrase inhibitors(IIS) are reported.