Our results strongly suggest that mutations of regulatory genes and the modulated expression of acrAB-tolC by the mar operon contribute to fluoroquinolone resistance and Mar phenotype,and the mutations of marR,soxR and acrR in the mutants correlated with fluoroquinolone resistance and Mar phenotype.

Simultaneous Determination of Sulfonamides and Fluoroquinolones Residues in Pork by Solid-phase Extraction and High Performance Liquid Chromatography;

Interactions Between Fluoroquinolones and Bovine Serum Albumin by Fluorescence Method and Affinity Capillary Electrophoresis;

Mutant prevention concentration of fluoroquinolones for Baumannii acinetobacter and its ciprofloxacin induced mutant strains;

The action mechanism of DNA Gyrase with the tittled compounds,selection and the structure- activity relationships of fluroquinolones are reviewed.

Objective Shigellosis was investigated among outpatients with diarrhea in Wuhan, serotype distribution and drug resistance of Shigellae was analyzed, the mechanism of fluroquinolones-resistant was studied and a genotyping method for Shigella spp.

Relation between fluoroquinolones-resistant and mutation of grlA and grlB gene in Staphylococcus aureus;

Synthesis and antibacterial activities of 7-{4-[2-[2-substituted-4-((5S)-5-acetylaminomethyl-2-oxo-oxazolidin-3-yl)-phenyl]-ethyl]-piperazin-1-yl}-fluoroquinolones;

A Study on the Difference of Efflux Protein Expression between Klebsiella Pneumoniae Used in Vitro Fluoroquinolone and Ones Not Used;

Progress about Drug Fast Mechanism of Enterococcus to Fluoroquinolones;

These new fluoroquinolones provide more choice for clinical doctors to treat infection patients, but we should use these fluoroquinolones reasonably in order to avoide bacteria resistance producing and the interaction between drugs.