1) second tyrosine kinase domain
FLT3基因突变
1.
This study was aimed to investigate the frequency of FMS-like tyrosine kinase 3(FLT3) mutations including internal tandem duplication(ITD) mutation of juxtamembrane region and point mutation of the second tyrosine kinase domain(TKD) in acute myeloid leukemia(AML) patients and its clinical significance.
结论:FLT3基因突变是AML患者中常见的突变,FLT3-ITD突变较FLT3-TKD点突变发生率高,FLT3-ITD有突变的AML患者预后差;FLT3-TKD点突变对预后的影响不明显。
2) FLT3/ITD mutation
FLT3/ITD基因突变
1.
The value detection of FLT3 gene and FLT3/ITD mutation in myelodysplastic syndromes;
骨髓增生异常综合征患者FLT3基因及FLT3/ITD基因突变的检测及价值
2.
Results The expression of FL T3 gene were detected in 43 AML patients with agarose gel and single-strand conformation polymorphism eletrophoresis;There was no FLT3/ITD mutation with agarose gel eletrophoresis,but FLT3/ITD mutation was detected in 15 cases(35%)with single-strand conformation polymorphism gel eletrophoresis.
方法采用多聚酶链反应(PCR)联合单链构象多态性(SSCP)方法检测43例不同免疫分型AML患者DNA水平FLT3基因及FLT3/ITD基因突变。
3) FLT_3 mutations
FLT3突变
1.
Objective:To investigate the FLT_3 mutations in leukemia patients by peripheral blood and indicate the relationship between FLT_3 mutations and the pathogenesis of leukemia.
结论Flt3基因突变和白血病发生、发展相关,外周血可以替代骨髓检测FLT3突变;FLT3-ITD阳性患者化疗缓解率低、易复发、预后差;外显子14、L567突变点是否为FLT3一个新的突变热点需进一步研究。
5) FLT3 gene
FLT3基因
1.
The value detection of FLT3 gene and FLT3/ITD mutation in myelodysplastic syndromes;
骨髓增生异常综合征患者FLT3基因及FLT3/ITD基因突变的检测及价值
2.
This study was aimed to explore the role of FLT3 gene in AML pathogenesis and its significanse for detection of MRD.
本研究旨在探讨FLT3基因在AML发病中的作用及对微小残留病(MRD)检测的意义。
补充资料：[3-(aminosulfonyl)-4-chloro-N-(2.3-dihydro-2-methyl-1H-indol-1-yl)benzamide]
分子式：C16H16ClN3O3S
分子量：365.5
CAS号：26807-65-8
性质：暂无
制备方法：暂无
用途：用于轻、中度原发性高血压。
分子量：365.5
CAS号：26807-65-8
性质：暂无
制备方法：暂无
用途：用于轻、中度原发性高血压。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条