OBJECTIVE To compare the sleep-wake profiles induced by endogenous prostaglandin (PG)D2 and CGS21680,an adenosine A2A receptor agonist.

Methods For cultured human RPE cells:immunohistochemistry was used to detect the A2A adenosine receptor in human RPE cells;cultured human RPE cells were treated with high glucose(33 mM)+adenosine deaminase(ADA,2 U/ml),high glucose+ADA+adenosine A2A receptor agonist(CGS21680,50 μM),high glucose +ADA +CGS21680 +adenosine A2A receptor antagonists(SCH58261,100 μM) for 24 h.

Objective:To examine the ultrastructural changes and expression of neuroinflammatory cytokines after exposure to chronic hypoxic hypercapnia,a mouse model of COPD,and to further investigate the effect of genetic inactivation of adenosine A2A receptor on these pathological changes.

Different effects of adenosine A2A receptors in the models of traumatic brain injury and peripheral tissue injury;

Adenosine A2A receptor:an important molecule for immunoregulation

According to the animal experiments in the past, A2A receptor antagonist can prevent the neuron from injury induced by ischemia, but the exact functional sectors and mechanism are still not clear and need the further discussion and exploration.

Advances in the study of A_(2B) adenosine receptor antagonists;

Progression of adenosine receptor in cerebral ischemia;

Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons;

Role of protein kinase C in adenosine A1 receptor regulating opening of mitochondria permeability transition pore in hypoxic cardiac myocytes;

Effect of adenosine A1 receptor in the rapid ischemic tolerance induced by pretreatment with single electroacupuncture in rats;