Current status of peptide deformylase and its inhibitors;

According to the structure-activity relationship of peptide deformylase inhibitors,a series of hydroxamic acid derivatives containing isoxazole were designed and synthesized based on the structure of actinonin.

The advance of the peptide deformylase inhibitor LBM-415;

Progresses in the investigations of peptide deformylase inhibitors;

Both the inhibitors of peptide deformylase and oxazolidinones are the foci on the research of novel totally-synthesized antibacterial agents which function by blocking the protein synthesis in bacterial cells.

Expression of functional formylpeptide receptor FPR by primary human malignant glioma cells;

Objective To observe the effects of Nordy,a synthetic compound,on the expression of formylpeptide receptor(FPR)and vascular endothelial growth factor(VEGF)in orthotopically implanted tumor in the brain of human malignant glioma-bearing nude mice and explore the mechanism of anti-tumor effect of Nordy.

To investigate the effects of nordy(25-100 μmol·L~(-1)) on the function of formylpeptide receptor(FPR) of malignant human glioma cells,human glioblastoma cell line U87 was used to detect its proliferation,migration,calcium mobilization,vascular endothelial growth factor(VEGF) mRNA and protein levels after activation of FPR by its agonist N-formyl-methionyl-leucyl-phenylalanine(fMLF).