The Nazarov cyclization, a powerful tool for the construction of five-membered carbocycles from divinyl ketones and related compounds, has attracted increasing attention in recent years due to its wide applications in the synthesis of complex natural and unnatural products.

In the first part of this dissertation, we have developed a single Lewis acid-catalyzed tandem Nazarov cyclization / electrophilic fluorination transformations of polarized enones into fluorine-containing 1-indanone derivatives.

In this paper,the title compound was synthesized through cyclization reaction of p-methylbenzoic acid,p-chloromethylbenzoic acid and p-nitrilbenzyl chloride with 4,6-diaminoresorcinol dihydrochloride.

The intermediate of Tinoxicam,4-hydroxy-3-methyl-2H-thieno-1,2-thiazine-2-(methyl) carboxylate-1,1-dioxide(MHTTCD) was synthesized from methyl 3-amino-2-thiophene methyl carboxylate through four steps: chlorosulfonylation,methylamination,N-alkylation,and cyclization.

The synthesis of furan phenol through cyclization were studied, catalyzed by aluminium alkoxide and the affect of the catalyst weight against the selection of furan phenol and the feeding in or distilling out of the alcohol against the reaction yield of product.

Starting from the routes of rearrangement reaction and cyclization reaction,the kinetic model for synthesizing benzofuranol from o-methallyloxyphenol was proposed.