A research on the relationship between six-meridian syndrome differentiation and six qi controlling heaven not only fills in the gaps of the theoretical study of circuit and qi,but also adds category for TCM diagnostics.

The essence of pathogenesis of the six endopathogens in Huangdi Neijing are six diseases and pathogenesis which get their names according to the patterns of wind,cold,summer,dampness,dryness,fire,the six climatic factors of the nature,so their essences are related to the method of analogizing from the similarity of the appearances of the diseases and natural phenomena.

This paper deals with the meanings and characteristics of the six climatic factors, the calculation methods for abnormal climate, the prediction of disease occurrence based on the transformation of the six climatic factors, and the relationship of the six climatic factors to gynecopathy.

"Six exogenous pathogenic factors transfer form fire" and "six exogenous pathogenic factors will turn into fire" emphasizes "fire-heat pathogenesis",which are generalized according to diseases caused by six exogenous pathogenic factors in SuWen XuanJi YuanBingShi(etiology based on plain questions)of LIU Wan-su.