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1)  dead layer
[导体的]死层
2)  activation-inducible tumor necrosis factor receptor ligand
活化可诱导的肿瘤坏死因子受体配体
3)  TNF-related apoptosis-inducing ligand
肿瘤坏死因子相关的凋亡诱导配体
1.
TNF-related apoptosis-inducing ligand and tumor therapy;
肿瘤坏死因子相关的凋亡诱导配体与肿瘤治疗
2.
Objective To observe the anti-tumor effect of combination TNF-related apoptosis-inducing ligand (TRAIL) with aspirin on liver cancer cell line, SMMC-7721.
目的 观察肿瘤坏死因子相关的凋亡诱导配体(TRAIL)与阿司匹林合用对肝癌SMMC-7721细胞的作用。
3.
TNF-related apoptosis-inducing ligand (TRAIL), a member of TNF family, attracts particular attention for its unique properties to induce cell apoptosis in many kinds of cancer cells while sparing most normal cells.
肿瘤坏死因子相关的凋亡诱导配体(TNF-related apoptosis-inducing ligand,TRAIL)是肿瘤坏死因子超基因家族中重要的一员,它能够诱导多种肿瘤细胞发生凋亡,而对正常细胞几乎无毒性,已成为一种新的具有开发潜力的抗肿瘤药物。
4)  Tumor necrosis factor related apoptosis inducing ligand
肿瘤坏死因子相关的凋亡诱导配体
1.
Objective To determine the synergistic effect of Smac on augmenting apoptosis induced by tumor necrosis factor related apoptosis inducing ligand(TRAIL)in human neuroblastoma cell line SK-N-SH.
目的研究Smac基因在肿瘤坏死因子相关的凋亡诱导配体(TRAIL)诱导的神经母细胞瘤(NB)SK-N-SH细胞凋亡中的增强作用。
5)  Tumor Necrosis Factor-related Apoptosis-inducing Ligand
肿瘤坏死因子相关的凋亡诱导配体
6)  TRAIL [英][treɪl]  [美][trel]
肿瘤坏死因子相关的凋亡诱导配体
1.
Objective: To synthesize the soluble TNF-related apoptosis-inducing ligand (TRAIL)cDNA and construct its prokaryotic expression vector.
目的:合成可溶性的肿瘤坏死因子相关的凋亡诱导配体(TRAIL)的cDNA,并构建其原核表达载体。
2.
Objective:To explore the induction of TRAIL gene expression by ATRA or As2O3 in NB4 cells and its theraputic value.
目的:研究全反式维甲酸(ATRA)或三氧化二砷(As_2O_3)诱导急性早幼粒细胞白血病(APL)NB4细胞肿瘤坏死因子相关的凋亡诱导配体(TRAIL)基因的表达及其治疗APL的机制。
3.
TRAIL(TNF-related apoptosis-inducing ligand) was discovered because of its sequence homology to TNF and FasL, which belongs to type II transmembrane protein as other members of TNF family.
肿瘤坏死因子相关的凋亡诱导配体(TNF-related apoptosis-inducing ligand, TRAIL),又称凋亡素-2配体(apoptosis receptor 2 ligand, Apo2L),是1995年发现的肿瘤坏死因子家族的新成员,和其它家族成员一样,同属Ⅱ型跨膜蛋白,由胞浆区(14个aa),跨膜区(26个aa)和胞膜外区(241个aa)组成,胞膜外区有蛋白酶作用位点,可以从外膜上被剪切下来,形成可溶性分子,也可以形成二/三聚体。
补充资料:肿瘤坏死因子
分子式:
CAS号:

性质:又称恶液质素(cachectin),淋巴毒素(lymphotoxin;LT)。注射卡介苗短小棒状杆菌和酵母多糖等制剂,再以内毒素攻击在小鼠、大鼠和兔等多种动物的血清中出现的一种能引起肿瘤出血性坏死的活性成分。含有唾液酸和半乳糖胺的一种糖蛋白,分子量约150 000。根据其产生来源和结构不同,可分为TNF-α和TNF-β两类,前者有单核-巨噬细胞产生,后者有活化T细胞产生,现已有基因重组技术制备。两类TNF的基本生物活性相似,除具有杀伤肿瘤细胞外,还有免疫调节,参与发热和炎症的发生。大剂量TNF-α可引起恶液质,医疗上可单独或白细胞介素2联合用于治疗肿瘤。

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