Objective:In order to establish an effective process to produce adenine arabinoside(ara-A),enzymatic synthesis of ara-A catalyzed by whole cells of Enterobacter aerogenes was studied.

The content of vidarabine(Ara-A)and the encapsulation percen-tage of vidarabine(Ara-A) in liposome (EN%)were determined with ultravioletspectrophotometry and HPLC.

With the assistance of microwave irradiation,vidarabine is afforded in high yields through 6 steps,starting with adenosine,which can be obtained cheaply and conveniently.

Methods 198 subjects were randomized into two groups:control group in which 98 cases were treated by Vidarabine Injection and treatment group in which 100 cases were treated by Vidarabine Injection and Chinese herbs.

Study on mechanism of apoptosis induced by Ara-C in leukemia HL-60 cells;

Effects of Ara-C on proliferation/apoptosis and bcl-2 gene expression of HL60 cell;

The mechanisms of inhibitory effect of Ara-C and bufalin on human leukemia cells;

Pufferfish type Ⅰ collagen extract prevented and cured myelosuppression induced by cyclophosphamide or diamminedichloroplatinum or cytosine arabinoside in mice;

Treatment of arsenic and cytosine arabinosideon refractory leukemia;

(-)-Epigallocatechin-3-gallate enhances anti-tumor effect of cytosine arabinoside on HL-60 cells;

Study on the preparation of cytarabine poly-alkyl-α-cyanoacrylate nanoparticles;

Research progress on pharmacokinetics of fludarabine and its synergistic effect with cytarabine;

The release characteristics in vitro of cytarabine (Ara-C) poly-alkyl-acyanoacrylate lyophilized nanoparticles for injection;