Recent advances in the study of antifungal lead compounds with new chemical scaffolds;

Chemical modification of lead compounds by monasacchrides and their derivatives;

In order to find screening rules suitable for lead compounds of pesticide,five descriptors:logarithm of partition coefficient of octanol/water(LogP),relative molar weight(MW),number of hydrogen-bond donors(NHD),number of hydrogen-bond acceptors(NHA),polar surface area(PSA)and carcinogenic and mutagenic toxicities of 242 fungicides,512 herbicides and 399 insecticides were calculated and analyzed.

Design, synthesis and biological activity of the novel lead compound ethyl 2-(2-chloro-4-trifluoromethylphenoxy)-4-trifluoromethyl-thiazole-5-carbonate;

Marine biological toxins——A kind of important lead compounds for new drug research;

A novel lead compound, 4-[4-(3, 4-dimethoxyphenyl)-2-methyl-thiazole-5-carbonyl] morpholine (5), was designed and synthesized from 3, 4-dimethoxyacetophenone via six steps: esterification, chlormation, ring condensation, and hydrolysis to form the free acid, followed by formation of the acid chloride which, when reacted with morpholine, produces the desired amide (5).

Methodology for quick finding of leading compounds based on botanical metabonomic concept of determination for mixture by 1H-NMR;

As leading compounds these stilenes were modified by alkylation, glycosylation and association on the basis of the theory of structure modification and the theory of structure-activity relationships.

Computer-aided drug design(CADD) which playing a hinging role during new drug research and development is a multi-subject crossing subject,especially the discovery and optimization of leading compounds.

The work of isolating, purifying and identifying new leading compounds from Rhodomela confervoides and Scylosiphon lomcnkirins w.