1) pesticide guide compound
农药先导化合物
1.
Some compounds, which conformed to the requirements of pesticide guide compound, were synthesized.
用 QSAR理论为指导 ,对吡虫啉农药分子进行结构改造 ,合成出数种达到农药先导化合物要求的化合物 ,具有进一步优化结构从而成为新农药的良好潜
2) lead compounds
药物先导化合物
1.
Combinatorial chemistry is a new strategy for discovery and optimization of lead compounds in drug design in 1990s.
组合化学是进入９０年代以来寻找及优化新药先导化合物的主要研究方法，其特点是改变了传统的逐一合成、逐一纯化、逐一筛选的模式，而是以合成和筛选化学库的形式完成寻找及优化药物先导化合物，极大地加快了药物先导化合物出现的速度。
3) lead compounds
先导化合物
1.
Recent advances in the study of antifungal lead compounds with new chemical scaffolds;
新结构类型抗真菌先导化合物的研究进展
2.
Chemical modification of lead compounds by monasacchrides and their derivatives;
糖类对先导化合物的化学修饰及其在药学中的应用
3.
In order to find screening rules suitable for lead compounds of pesticide,five descriptors:logarithm of partition coefficient of octanol/water(LogP),relative molar weight(MW),number of hydrogen-bond donors(NHD),number of hydrogen-bond acceptors(NHA),polar surface area(PSA)and carcinogenic and mutagenic toxicities of 242 fungicides,512 herbicides and 399 insecticides were calculated and analyzed.
为了寻找适合于农药的先导筛选规则,对242个杀菌剂、512个除草剂和399个杀虫剂的5个描述符:疏水常数(LogP)、相对分子质量(MW)、氢键给体数(NHD)、氢键受体数(NHA)、分子极性表面积(PSA)和毒性进行了计算和分析,提出了杀菌剂、除草剂和杀虫剂先导化合物的筛选规则。
4) lead compound
先导化合物
1.
Design, synthesis and biological activity of the novel lead compound ethyl 2-(2-chloro-4-trifluoromethylphenoxy)-4-trifluoromethyl-thiazole-5-carbonate;
新型先导化合物2-(2-氯-4-三氟甲基苯氧基)-4-三氟甲基噻唑-5-甲酸乙酯的设计、合成与生物活性
2.
Marine biological toxins——A kind of important lead compounds for new drug research;
海洋生物毒素——一类重要的新药研究先导化合物
3.
A novel lead compound, 4-[4-(3, 4-dimethoxyphenyl)-2-methyl-thiazole-5-carbonyl] morpholine (5), was designed and synthesized from 3, 4-dimethoxyacetophenone via six steps: esterification, chlormation, ring condensation, and hydrolysis to form the free acid, followed by formation of the acid chloride which, when reacted with morpholine, produces the desired amide (5).
以3,4-二甲氧基苯乙酮为原料,经酯化、氯化、环化、水解、酰氯化和胺化六步制得新型先导化合物4-[4-(3,4-二甲氧苯基)-2-甲基噻唑-5-甲酰基]吗啉(5)。
5) leading compounds
先导化合物
1.
Methodology for quick finding of leading compounds based on botanical metabonomic concept of determination for mixture by 1H-NMR;
基于植物代谢组学混合物氢谱测定概念快速发现先导化合物的方法学研究
2.
As leading compounds these stilenes were modified by alkylation, glycosylation and association on the basis of the theory of structure modification and the theory of structure-activity relationships.
合成了55种化合物,其中有16种结构简单的芪类化合物和20种修饰产物,前者经初步活性检测表明:化合物1、3、4、6具有抑制肿瘤细胞的活性;以它们为先导化合物,根据先导化合物的结构修饰和构效关系理论,进行了以下修饰。
3.
Computer-aided drug design(CADD) which playing a hinging role during new drug research and development is a multi-subject crossing subject,especially the discovery and optimization of leading compounds.
计算机辅助药物设计(CADD)是多学科交叉的边缘学科,在药物研发过程中起着枢纽作用,特别在先导化合物的发现和优化中发挥重要作用。
6) leading compound
先导化合物
1.
The work of isolating, purifying and identifying new leading compounds from Rhodomela confervoides and Scylosiphon lomcnkirins w.
并对其中生物量较大的松节藻、萱藻进行了先导化合物的分离纯化和结构鉴定，从中分离纯化出色素、甾醇、甘油酯和溴酚类化合物30多个，并运用一维核磁共振(~1HNMR、~(13)CNMR、DEPT)、二维核磁共振(~1H-~1Hcosy、HMBC、HMQC)、红外光谱(IR)、质谱(EI/MS、FAB/MS)等现代波谱分析技术分析鉴定了化合物15个，其中15个为新化合物，1个为首次从自然界中分离得到。
补充资料：先导化合物
分子式：
CAS号：
性质：能够进行各种结构修饰的母体化合物或活性分子设计最初产生的结构图像。这种母体化合物或图像能进行结构修饰，并衍生出一系列新化合物，借以发现高活性分子结构。
CAS号：
性质：能够进行各种结构修饰的母体化合物或活性分子设计最初产生的结构图像。这种母体化合物或图像能进行结构修饰，并衍生出一系列新化合物，借以发现高活性分子结构。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条