The tumor-suppressing effects of rhIL-24 protein on B16 cells in vitro and in vivo;

Effect of ethacridine on the growth and the expression of MMP-2 and MMP-9 of B16 melanoma cells;

[Methods] The C57BL/6J mice bearing melanoma B16-F1 cells were intragastric with tetramethylpyrazine 100, 200 mg/(kg·d) for 20 days, then the weight of lungs, spleens, the number of the metastatic nodules on lungs and the levels of iNOS and NO in serum were detected.