On the basis of this, 1,3-dipolar cycloaddition reactions were studied using imine esters as the starting marerials.

The influences of the frontier molecular orbitals and optimized geometry of the precursor on the reaction rates and endo/exo selectivity are discussed,and a reasonable explanation about the steroselectivity of 1,3-dipolar cycloaddition reaction in the presence of copper-(Ⅱ)-or.

The effect of the complexes of copper(II) or zinc(II) with 2,2-bis[2,2′-4(S)-benzyl-4,5-dihydrooxazole]propane catalysis on the 1,3-dipolar cycloaddition reactions of diphynyl nitrone with electron-rich ethyl vinyl ether under various reaction conditions is determined.

2%,1-Benzyl-5-phenyl-1,2,3-triazole was prepared through 1,3-dipolar cycloaddition reaction with benzylazide and phenylacetylene,and the yield was 26%.

The triazole compounds(7b and 8b) were obtained by dipolar-cycloaddition reaction from 3b and some carbonyl nucleophilic reagents containing active methylene.

Development of complex in catalytic enantioselective 1,3-dipolar cycloaddition reactions of nitrones;

Novel 4-β-D-allopyranosyloxy-α-chloro-benzaldehydeoxime (3) was synthesized by substitution reaction of 2 with t-BuOCl, and novel 3-(4-β-D-allopyranosyloxyphenyl)-4-aryl-5-aryl-1,2,4-oxadiazoline derivatives (5a～5h) have been synthesized by 1,3-dipolar cycloaddition reaction of 3 with Schiff bases 4a～4h.

Six novel 3-(p-methoxyphenyl)-5-aryl-3a,6a-dihydro-4,6-dioxo-pyrrolino[3′,4′-d]isoxazole derivatives(3a~3f) were synthesized by 1,3-dipolar cycloaddition reaction of N-arylmaleimides and 4-methoxybenzonitrile oxide in the presence of Et3N.