In this review,DNA methylation mechanism,relationship between aberrant methylation and hematologic malignancies,mechanism of demethylation therapy,the advance of research on the demethylation therapy of hematological malignancies,such as acute and chronic leukemia,lymphoma,myelodysplastic syndrome were summarized.

Effects of inhibitors of demethylation and histone deacetylase on the growth and apoptosis of ishikawa and AN3 cell lines;

Growth Inhibition and Demethylation by a Component of Natural Drug, CDP, in Cancer Cell Lines;

Study on p73 Gene Methylation and Demethylation in Non-Hodkin s Lymphomas;

The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.

Lysine specific demethylase 1(LSD1) is the first histone demethylase,acting on demethylation of mono-and di-methylated histone H3 on lysine 4(H3K4) and lysine 9(H3K9) and regulating target gene\'s transcription.

Taking two varieties of broccoli Qingfeng 103 and Luxiu as materials,we adopted different 5-azaC treatments on them at young seedling stage,tested the influence of DNA demethylation on vernalization and C/N during vernalization in broccoli.