The study was purposed to investigate the possible mechanism of epigallocatechin-3-gallate(EGCG) induced p16 gene demethylation and transcription regulation in the malignant lymphoma cell line-CA46.

Diagnosis of early stage lung cancer by low-dose spiral CT combined with serum p16 gene methylation;

Low-dose computed tomography and serum p16 gene methylation measurement for screening of early lung cancer

Objective To determine the feasibility of conducting low-dose computed tomography (LDCT) and serum P16 gene methylation measurement for early diagnosis of lung cancers in symptomatic individuals at high risk of lung cancer.

Study of chromosome abnormalities and p16 gene methylation in the patients with MDS;

Research of expression of p16 gene in K562/A02 cell line;

Antitumor efficacy of the adenoviral vector expressing p16 gene targeting the hepatocellular carcinoma models on nude mice;

The clinical significance of C-myc and P16 gene s expression in hepatocellular carcinoma;

Detection of methylation of p16 gene by nested methylation specific polymerase chain reaction;

Correlation of p16 hypermethylation with tumorigenesis and the development of gastric cancer;

Effects of exogenous p16 gene on the cell cycle and growth of renal carcinoma cell;