New advances have been made in the study of Escherichia coli AcrAB-TolC efflux pump structure and its regulation, which provides data for the multidrug resistance research in pathogenic bacterium.

This article reviewed the hazard to livestock and mankind caused by Shigella,the classification of Shigella and its state of multidrug resistant in clinic,and also the feature of main drug resistance system acrAB-tolC and advance of drug resistance related gene:hdeA,tolB,tolA,tolQ,the medicamentous outside transport protein:marA,acrA,acrB etc.

The mechanism of efflux pumps in clinical isolated multidrug-resistant Pseudomonas aeruginosa strains;

The mechanism of bacterial efflux pumps is one of the important factors resulting in bacterial multidrug resistance.

Objective To establish an efflux pump inhibitor screening model with the out-membrane protein OprM in Pseudomonas aeruginosa efflux pump system as the target point.