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1)  Alcaligenes faecalis penicillin G amidase
粪产碱杆菌青霉素酰化酶
2)  Alcaligenes faecalis
粪产碱杆菌
1.
Antibacterial Effect of the Total Extract of Hypericum perforatum L. on Corynebacterium glutamicum and Alcaligenes faecalis;
贯叶连翘总提取物对谷氨酸棒状杆菌和粪产碱杆菌的抗菌作用
2.
Enhanced Production of Curdlan by Alcaligenes faecalis by Selective Feeding with Ammonia Water during the Cell Growth Phase of Fermentation;
氨水流加用于粪产碱杆菌热凝胶发酵
3.
Purification and Characterization of Alcaligenes faecalis Penicillin G Acylase;
粪产碱杆菌青霉素G酰化酶的分离纯化及酶学性质
3)  Penicillin G acylase
青霉素G酰化酶
1.
Purification and Crystalline of Penicillin G Acylase;
大肠杆菌108(pPAHD1)青霉素G酰化酶的纯化与结晶
2.
Site-directed mutagenesis of B.megaterium penicillin G acylase and its kinetics;
巨大芽孢杆菌青霉素G酰化酶的定点突变及其动力学性质研究
3.
Site-directed Mutagenesis at Ser177 of Penicillin G Acylase Gene;
青霉素G酰化酶基因Ser177的定点突变
4)  Penicillin G acylase
青霉素酰化酶
1.
Immobilization of penicillin G acylase with a layer material ——ayered double hydroxide;
层状材料水滑石固定青霉素酰化酶的研究
2.
Penicillin G acylase can catalyze the cleavage of the amide bond in the benzyl penicillin(penicillin G)side-chain to yield phenylacetic acid and 6-aminopenicillanic acid(6-APA).
利用扩孔剂的作用合成出较大孔径(12nm)的介孔材料SBA-15,并进行表面氨基修饰,以此为载体,以戊二醛为交联剂,对青霉素酰化酶进行组装固定,并对固定化青霉素酰化酶(PGA)的稳定性进行了深入的研究。
3.
The structural characteristics,surface properties and immobilization for penicillin G acylase(PGA) of the mesoporous supports were investigated by XRD,N2-adsorption and FT-IR spectrum.
采用XRD、低温N2吸附及FT-IR等方法研究了介孔载体的结构特征、表面酸性和对青霉素酰化酶(Penicillin G Acylase,PGA)的固定化作用。
5)  penicillin acylase
青霉素酰化酶
1.
Immobilization of penicillin acylase by intensive adsorption of chitosan on celite;
硅藻土强化吸附壳聚糖固定化青霉素酰化酶
2.
Applications of flocculating agents in extraction of penicillin acylase;
絮凝剂在青霉素酰化酶提取中的应用
3.
A New Carrier for immobilization of penicillin acylase;
固定化青霉素酰化酶的新载体
6)  penicillin G amidase
青霉素酰化酶
1.
Reactive, macroporous and beaded glycidyl methacrylate (GM) copolymer bearing epoxy groups and amide groups was synthesized by inverse suspension polymerization and used as the support for the immobilization of penicillin G amidase (PGA).
用共价键合法将青霉素酰化酶固定化在珠状多孔的甲基丙烯酸缩水甘油酯 (GM)共聚物上 ,研究了固定化反应时间、温度、pH值和酶液用量对固定化青霉素酰化酶的表观活性、表观偶联效率、活性回收及稳定性的影响 。
2.
Reactive, macroporous and beaded glycidyl methacrylate copolymer bearing oxirane groups and amide groups was synthesized by inverse suspension polymerization and used as the support for the immobilization of penicillin G amidase.
应用反相悬浮技术合成了珠状甲基丙烯酸缩水甘油酯 - N ,N′-亚甲基双 (丙烯酰胺 )共聚物 ,并将巨大芽孢杆菌 ( Bacillus megaterium)青霉素酰化酶共价偶联到甲基丙烯酸缩水甘油酯共聚物载体上 ,制成固定化青霉素酰化酶 ,其表观活性为 3 71 U/g(干重 ) ,水解青霉素 G钾盐的最适温度为 47°C,最适 p H为 8。
3.
Mesoporous molecular sieve MCM - 41 has been used as the support for the immobilization of penicillin G amidase(PGA) .
通过改变酶固定化时的pH值、温度、时间以及酶用量,研究了固定化条件对MCM-41载体上固定化青霉素酰化酶的酶活及其稳定性的影响,明确了酶活及其稳定性随固定化条件的变化规律,初步分析了青霉素酰化酶在介孔分子筛MCM-41上的固定化过程。
补充资料:产青霉素酶淋球菌
分子式:
CAS号:

性质:由于青霉素类抗生素在临床上广泛应用于各种细菌感染包括淋球菌感染的治疗,但淋球菌与青霉素类抗生素接触后,易诱导产生青霉素酶,灭活抗生素,使治疗失败。淋球菌中产生青霉素酶的菌株可达5%~10%,甚至更高,造成对青霉素类抗生素高度耐药,对头孢菌素和大观霉素交叉耐药。通常淋球菌产生的酶属于质粒介导的青霉素酶。对该酶不稳定的青霉素类抗生素,易被水解失去抗菌活性。临床上选用药物治疗时,应以药物敏感试验为依据。

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