The Method and Parallel Processing for Fragment Assembly in Whole Genome DNA Sequecing Project;

One of the practical difficulties that remains in largescale DNA fragment assembly is the correct reconstruction of DNA sequences including repeats.

This paper proposes a pre-merged repeats masking-off method by studying repeats analysis in DNA fragment assembly.

This thesis introduces the arc splines fixing with sectionally smooth joining to create the computing modeling for disk cam with wedge flatface follower,analyze the fixing error of the model and solve the problem of it’s manufacturing with the numeric control continuous contouring grinder.

The similarity between two contour curves was determined by comparing feature vectors of two contour curves,and contour curve matching and fragment mosaicing were realized.