By analyze the reasons that venous seepage of intense irritant drugs in 56 cases caused different degree damage to local skin tissue,we think that inflammatory changes and necrosis of skin have direct relationship with drug concentration,osmotic pressure,particles in liquid,temperature,diameter of blood vessel,children age,infusion speed,responsibility and technique of nurse.

Clinical study on comfort of patients accepted modified method to infuse irritant drugs intravenously;

Conclusion:The drug stimulus brings about the change of metaphysis and promotes proliferation of chondrocyte and osteoblast in metaphysis,which illustrates that drug stimulation can cause tibia metaphysis to expand longitudinally and thicken laterally.

Observation on effect of povidone iodine cream external applying to treat patients with strong irritative drugs exosmosis