1) replicative oncolyitc adenovirus
增殖性溶瘤腺病毒
1.
ZD55-IL-24 is a replicative oncolyitc adenovirus carrying tumor-specific interleukin-24 gene and targeting tumor cells with loss of p53.
增殖性溶瘤腺病毒ZD55-IL-24是靶向p53缺失且携带肿瘤特异性的白细胞介素-24基因(IL-24);丝裂霉素(mitomycin C,MMC)是一种目前临床上癌症治疗常用化疗药物之一。
2) HCC-specific CRAd
溶瘤性腺病毒
3) conditionally replicating adenovirus
肿瘤增殖型腺病毒
1.
Objective To construct the conditionally replicating adenovirus vector Ad-delE1b55kD-shRNA/Survivin-EGFP that can transfects into HT-29 effectually and selectively and contains shRNA targeting to human Survivin gene.
目的构建特异性强,转染率高,针对人Survivin进行RNA干扰的肿瘤增殖型腺病毒载体(Ad-delE1b55kD-shRNA/Survivin-EGFP)。
2.
Objective To Construct the conditionally replicating adenovirus vector Ad-delE1b55KD-shRNA/Survivin-EGFP which can transfect to HT-29 effectually and selectively and containing shRNA to human Survivin gene.
目的:构建特异性强,转染率高,携带针对人Survivin的shRNA的肿瘤增殖型腺病毒载体,研究其介导的以人Survivin为靶标的RNA干扰对结肠癌细胞株HT-29中Survivin mRNA和蛋白的表达、对结肠癌细胞HT-29增殖和凋亡的影响、时效性及其意义,探讨肿瘤增殖型腺病毒介导RNA干扰对结肠癌的治疗作用。
4) replication-competent adenovirus
肿瘤特异增殖型腺病毒
1.
Construction of replication-competent adenovirus shuttle plasmids pAd-delE1b55kD;
肿瘤特异增殖型腺病毒穿梭质粒pAd-delE1b55kD的构建
5) replicate adenovirus
增殖腺病毒
1.
Objective The selective replicate adenovirus was used to express mouse interleukin 12 (mIL12) in order to enhance the therapeutic effects on the nasopharyngeal carcinoma (NPC).
目的 肿瘤选择性增殖腺病毒携带小鼠白细胞介素 1 2 (mIL1 2 )基因 ,增强对鼻咽癌细胞的杀伤作用。
6) oncolytic adenovirus
溶瘤腺病毒
1.
Effects of oncolytic adenovirus H101 treatment on tumor tissue of nude mice transplanted with human esophageal carcinoma cells induced by carcinoembryonic antigen gene silencing
癌胚抗原基因抑制对溶瘤腺病毒H101治疗人食管癌裸鼠皮下移植瘤的影响
2.
To reduce the killing effect of oncolytic adenovirus on normal cells and get safe clinical application,oncolytic adenovirus AdCN103,a novel dual-targeting tumor specific proliferating virus,was constructed by replacing the wild type adenovirus E1A promoter with the promoter of human telomerase reverse transonptase(hTERT) and mutant E1A lacking CR2 region.
为了降低溶瘤腺病毒对正常细胞的杀伤作用,提高临床应用上的安全性,构建了一种双靶向溶瘤增殖型腺病毒AdCN103,以人端粒酶逆转录酶(hTERT)启动子代替野生型腺病毒E1A自身的启动子,同时在E1A区缺失保守区域CR2的24bp。
3.
To develop a novel gene therapeutic oncolytic adenovirus in which the hTERT promoter was introduced and used to regulate adenoviral E1A gene.
为构建一种由人端粒酶逆转录酶启动子(hTERTp)调控的能够在肿瘤细胞中特异性增殖的新型肿瘤基因治疗溶瘤腺病毒载体系统,利用基因重组技术将hTERTp插入5型腺病毒E1A基因上游,构建肿瘤特异性增殖腺病毒AdSU,使其携带绿色荧光蛋白报告基因。
补充资料:增殖
分子式:
CAS号:
性质:可转换核素238U、232Th俘获1个中子后分别转化成易裂变核素239pu和233U。在增殖反应堆中,每消耗1个易裂变材料的原子核平均生成的新易裂变材料的原子核多于1个。这种生产更多易裂变物质的过程称为增殖。增殖的效率通常用倍增时间来表示。
CAS号:
性质:可转换核素238U、232Th俘获1个中子后分别转化成易裂变核素239pu和233U。在增殖反应堆中,每消耗1个易裂变材料的原子核平均生成的新易裂变材料的原子核多于1个。这种生产更多易裂变物质的过程称为增殖。增殖的效率通常用倍增时间来表示。
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参考词条